172215-91-7

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Bromo-4-(trifluoromethyl)aniline is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 3-Bromo-4-(trifluoromethyl)aniline serves as a crucial component in the production of pesticides and other crop protection agents, contributing to enhanced crop yields and protection against pests.
Used in Dye and Pigment Manufacturing:
3-Bromo-4-(trifluoromethyl)aniline is utilized as a starting material in the manufacturing of dyes and pigments, providing a wide range of color options for various applications, including textiles, plastics, and printing inks.
Used in Specialty Chemicals Production:
As an intermediate, 3-Bromo-4-(trifluoromethyl)aniline is employed in the production of specialty chemicals, catering to specific industrial needs and applications.
Available for Research and Industrial Applications:
3-Bromo-4-(trifluoromethyl)aniline is accessible for purchase from various chemical suppliers, making it a valuable resource for both research and industrial purposes, where its unique properties can be further explored and applied.

Upstream product

• 887144-94-7 Togni's reagent II 
• 591-19-5 m-Bromoaniline 
• 16426-64-5 2-bromo-4-nitrobenzoic acid 
• 875238-74-7 2-bromo-4-nitro-1-(trifluoromethyl)benzene 

Downstream Products

• 1193384-47-2 5-(methylthio)-2-nitro-4-(trifluoromethyl)benzenamine 
• 1373233-07-8 5-bromo-2-iodo-4-(trifluoromethyl)aniline 

Relevant academic research and scientific papers

Deoxofluorination of (Hetero)aromatic Acids

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

Nickel-Catalyzed Direct C-H Trifluoromethylation of Free Anilines with Togni's Reagent

An efficient nickel-catalyzed C-H trifluoromethylation for the synthesis of trifluoromethylated free anilines using Togni's reagent has been developed. This approach exhibits a good functional group tolerance, good regioselectivity, and chemoselectivity under mild conditions. The newly developed economical one-step method is a better alternative to synthesize trifluoromethylated free anilines.

Preparation method of trifluoromethylamine

The invention relates to a preparation method of trifluoromethylamine. The method includes the following steps that aromatic amine shown in the formula (1) and a trifluoromethyl reagent shown in the formula (2) react in a solvent under the condition that an alkali and/or nickel compound exists, and the trifluoromethylamine compound shown in the formula (3) is generated. According to the preparation method of trifluoromethylamine, aromatic amine and 1-trifluoromethyl-1,2-iodobenzoyl-3(H)-ketone serve as raw materials and react under the condition that the alkali and/or nickel compound exists through the amino positioning effect on aromatic nucleus. The synthesis steps of the method are simple, the cost of the raw materials is low, the production cost of trifluoromethylamine can be greatly reduced, and large-scale industrialized production is promoted.

Visible-light-promoted radical C-H trifluoromethylation of free anilines

The trifluoromethyl-substituted anilines are biologically active compounds and useful building blocks. In this communication, we have developed the first visible-light-induced radical trifluoromethylation of free anilines with the commercially available and easily handled Togni reagent at room temperature. The resulting products were successfully transformed into a variety of valuable fluorine-containing molecules and heterocyclic compounds. This protocol provides an economical and powerful route to trifluoromethylated free anilines.