17222-74-1Relevant academic research and scientific papers
New approach towards the synthesis of selenosemicarbazones, useful compounds for Chagas' disease
Pizzo, Chiara,Faral-Tello, Paula,Yaluff, Gloria,Serna, Elva,Torres, Susana,Vera, Ninfa,Saiz, Cecilia,Robello, Carlos,Mahler, Graciela
, p. 107 - 113 (2016/01/15)
Herein, we describe a new approach towards the synthesis of selenosemicarbazones. The reaction involves an O-Se exchange of semicarbazones using Ishihara reagent. Eleven selenosemicarbazones were prepared using this methodology, with low to moderate yields. Among the prepared compounds the m-bromo phenyl methyl derivative 1b was selected to be evaluated in vivo, in a murine model of acute Chagas' disease. Compound 1b 10 mg/kg bw/day reduced 50% of parasitaemia profile compared with the control group, but was less effective than Benznidazole (50 mg/kg bw/day reduced 90%) and toxic. These studies are important to guide future Chagas drug design.
Heterocycles 23: Synthesis, characterization and anticancer activity of new hydrazinoselenazole derivatives
Zaharia, Valentin,Ignat, Adriana,Ngameni, Bathelemy,Kuete, Victor,Moungang, Marlyse L.,Fokunang, Charles N.,Vasilescu, Mihai,Palibroda, Nicolae,Cristea, Castelia,Silaghi-Dumitrescu, Luminita,Ngadjui, Bonaventure T.
, p. 5670 - 5679 (2013/11/06)
A series of novel functionalized 1,3-selenazole was synthesized by Hantzsch-type condensation reaction and evaluated for their in vitro cytotoxic activity against two human cancer cell lines. The structures of the synthesized selenosemicarbazones and func
