17222-74-1

Basic information

• Product Name: (p-methoxy-benzyliden)-selenosemicarbazide
• Synonyms: (p-methoxy-benzyliden)-selenosemicarbazide
• CAS NO: 17222-74-1
• Molecular Weight: 256.166
• Mol File: 17222-74-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (p-methoxy-benzyliden)-selenosemicarbazide(CAS DataBase Reference)
• NIST Chemistry Reference: (p-methoxy-benzyliden)-selenosemicarbazide(17222-74-1)
• EPA Substance Registry System: (p-methoxy-benzyliden)-selenosemicarbazide(17222-74-1)

Safety Data

• Hazardous Substances Data: 17222-74-1(Hazardous Substances Data)

Upstream product

• 6292-71-3 4-methoxybenzaldehyde semicarbazone 
• 123-11-5 4-methoxy-benzaldehyde 
• 21198-79-8 selenosemicarbazide 
• 21198-80-1 acetone selenosemicarbazone 

Downstream Products

• 109054-53-7 4-phenyl-[2-(4-metoxy-benzyliden)-hydrazinyl]-1,3-selenazole 

Relevant articles and documents

New approach towards the synthesis of selenosemicarbazones, useful compounds for Chagas' disease

Herein, we describe a new approach towards the synthesis of selenosemicarbazones. The reaction involves an O-Se exchange of semicarbazones using Ishihara reagent. Eleven selenosemicarbazones were prepared using this methodology, with low to moderate yields. Among the prepared compounds the m-bromo phenyl methyl derivative 1b was selected to be evaluated in vivo, in a murine model of acute Chagas' disease. Compound 1b 10 mg/kg bw/day reduced 50% of parasitaemia profile compared with the control group, but was less effective than Benznidazole (50 mg/kg bw/day reduced 90%) and toxic. These studies are important to guide future Chagas drug design.