172225-71-7

Basic information

• Product Name: (S)-2-(3-tert-Butoxycarbonylamino-propionyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester
• CAS NO: 172225-71-7
• Molecular Weight: 809.085
• Mol File: 172225-71-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-(3-tert-Butoxycarbonylamino-propionyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(3-tert-Butoxycarbonylamino-propionyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester(172225-71-7)
• EPA Substance Registry System: (S)-2-(3-tert-Butoxycarbonylamino-propionyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester(172225-71-7)

Safety Data

• Hazardous Substances Data: 172225-71-7(Hazardous Substances Data)

Upstream product

• 3303-84-2 3-(tert-butyloxycarbonylamino)propionic acid 
• 1026176-43-1 (S)-2-Hydroxy-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 172225-78-4 (S)-2-(4-Methoxy-benzyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 172225-74-0 (4R,5S)-3-[(2R,3S)-3-Hydroxy-5-methoxymethoxy-2-((E)-styryl)-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one 
• 1027043-80-6 Toluene-4-sulfonic acid (2S,3S)-3-hydroxy-5-methoxymethoxy-2-((E)-styryl)-pentyl ester 
• 1026075-66-0 (S)-2-(4-Methoxy-benzyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-(2-hydroxy-ethyl)-2-methyl-4-phenyl-but-3-enyl ester 
• 1027174-40-8 (S)-2-(4-Methoxy-benzyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-2-methyl-1-(2-oxo-ethyl)-4-phenyl-but-3-enyl ester 
• 352281-78-8 (E)-(3S,4R)-3-Methoxymethoxy-4-methyl-6-phenyl-hex-5-en-1-ol 
• 219606-82-3 (2S,2'R)-benzyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate 
• 162473-70-3 (E)-(3S,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-6-phenyl-hex-5-en-3-ol 
• 37755-48-9 benzyl (2S)-2-hydroxy-4-methylpentanoate 
• 302600-51-7 (R)-2-((2E,7E)-(5S,6R)-5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-3-(4-methoxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester 
• 326473-59-0 (2S)-2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoic acid 
• 172225-75-1 (2S,3S)-5-Methoxymethoxy-2-((E)-styryl)-pentane-1,3-diol 

Downstream Products

• 162473-78-1 desepoxyarenastatin A 

Relevant articles and documents

Synthesis of stable analogs in blood and conformational analysis of arenastatin A, a potent cytotoxic spongean depsipeptide

In order to produce stable analogs in blood of arenastatin A, a potent cytotoxic depsipeptide from the marine sponge Dysidea arenaria, we synthesized four analogs in which the 15-20 ester linkage was modified. Among them, the carba analog and 20-deoxo analog showed stability in serum. The conformation of arenastatin A and its three analogs were analyzed by distance-restrained molecular dynamic calculation to elucidate a three-dimensional stereostructure contributing to the extremely potent cytotoxicity of arenastatin A.