172255-99-1 Usage
Chemical structure
A synthetic organoselenium compound with a pyrimidinone core and various substituents.
Molecular weight
415.37 g/mol
Appearance
Yellow crystalline solid
Solubility
Soluble in organic solvents like methanol, ethanol, and dimethyl sulfoxide (DMSO)
Anti-inflammatory activity
Exhibits potential anti-inflammatory properties, which can be beneficial in treating inflammatory conditions.
Antioxidant activity
Potent antioxidant and free radical scavenging properties, which can protect cells from oxidative stress and damage.
Cytoprotective activity
Provides cytoprotection by preventing cell damage and promoting cell survival.
Therapeutic potential
Investigated for the treatment of neurodegenerative disorders, inflammatory conditions, bipolar disorder, stroke, and cancer.
COVID-19 treatment
Demonstrated potential as a treatment for COVID-19 by inhibiting viral replication and reducing inflammation.
Mechanism of action
Ebselen is believed to act as a selenoenzyme mimic, reacting with reactive oxygen species (ROS) and peroxynitrite to form selenol intermediates, which can further react with other ROS or regenerate the parent compound.
Safety profile
Generally considered safe, but further research is needed to establish optimal dosages and potential side effects.
Synonyms
Ebselen, 1-[(benzyloxy)methyl]-5-(1-methylethyl)-6-[(3-methylphenyl)selanyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
Chemical classification
Organoselenium compound, Seleno-organic compound, Pyrimidinone derivative
Research focus
Ongoing studies to explore its potential applications in various therapeutic areas and to better understand its mechanisms of action.
Check Digit Verification of cas no
The CAS Registry Mumber 172255-99-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,2,5 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 172255-99:
(8*1)+(7*7)+(6*2)+(5*2)+(4*5)+(3*5)+(2*9)+(1*9)=141
141 % 10 = 1
So 172255-99-1 is a valid CAS Registry Number.
172255-99-1Relevant articles and documents
Synthesis and anti-HIV-1 activity of a series of 1-(alkoxymethyl)-5-alkyl-6-(arylselenenyl)uracils and -2-thiouracils
Kim, Dae-Kee,Kim, Young-Woo,Gam, Jongsik,Kim, Ganghyeok,Lim, Jinsoo,Lee, Namkyu,Kim, Hun-Taek,Kim, Key H.
, p. 1275 - 1283 (2007/10/03)
A series of 1-(alkoxymethyl)-5-alkyl-6-(phenylselenenyl)uracils and -2-thiouracils modified at the 3- and/or 5-posiuon of the C-6 phenylselenenyl ring with methyl or fluoro substituent has been synthesized and tested for their ability to inhibit HIV-1 rep
