172348-56-0

Basic information

• Product Name: 1-N-Cbz-4-N-(Boc-aminomethyl)piperidine
• Synonyms: N-Cbz-4-(Boc-animomethyl)piperidine;1-N-Cbz-4-N-(Boc-aminomethyl)piperidine;benzyl 4-((tert-butoxycarbonylamino)methyl)piperidine-1-carboxylate;REF DUPL: 1-N-Cbz-4-Boc-(Aminomethyl)piperidine;1-Cbz-4-(Boc-aMinoMethyl)piperidine
• CAS NO: 172348-56-0
• Molecular Formula: C19H28N2O4
• Molecular Weight: 348.44
• Mol File: 172348-56-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 484.5 °C at 760 mmHg
• Flash Point: 246.8 °C
• Appearance: /
• Density: 1.117 g/cm³
• Refractive Index: 1.523
• Storage Temp.: 2-8°C
• PKA: 12.72±0.46(Predicted)
• CAS DataBase Reference: 1-N-Cbz-4-N-(Boc-aminomethyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-Cbz-4-N-(Boc-aminomethyl)piperidine(172348-56-0)
• EPA Substance Registry System: 1-N-Cbz-4-N-(Boc-aminomethyl)piperidine(172348-56-0)

Safety Data

• Hazardous Substances Data: 172348-56-0(Hazardous Substances Data)

Usage

General Description

1-N-Cbz-4-N-(Boc-aminomethyl)piperidine is a chemical compound featuring a piperidine ring with a N-Cbz protective group at the 1-position and a N-(Boc-aminomethyl) protective group at the 4-position. The N-Cbz group, also known as the benzyloxycarbonyl group, is commonly used as a protective group for amines and is derived from benzoic acid and chlorine. The N-(Boc-aminomethyl) group, on the other hand, is derived from tert-butoxycarbonyl (Boc) and is commonly used as a protective group for amines as well. 1-N-Cbz-4-N-(Boc-aminomethyl)piperidine has potential applications in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals, due to its role as a building block for more complex molecules.

InChI:InChI=1/C19H28N2O4/c1-19(2,3)25-17(22)20-13-15-9-11-21(12-10-15)18(23)24-14-16-7-5-4-6-8-16/h4-8,15H,9-14H2,1-3H3,(H,20,22)

Upstream product

• 7144-05-0 4-Aminomethylpiperidine 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 132431-09-5 benzyl (piperidin-4-ylmethyl)carbamate 
• 157023-34-2 4-aminomethyl-piperidine-1-carboxylic acid benzyl ester 

Downstream Products

• 172348-57-1 [1-(benzyloxycarbonyl)-4-piperidyl] methylamine hydrochloride 
• 135632-53-0 tert-butyl N-(4-piperidinylmethyl)carbamate 

Relevant articles and documents

NOVEL TRICYCLIC PIPERIDINYL COMPOUNDS USEFUL AS INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Novel tricyclic compounds of formula (1.0) or a pharmaceutically acceptable salt or solvate thereof, wherein: one of a, b, c, and d represents N or NR, wherein R is O-, -CH3 or -(CH2)nCO2H wherein n is 1 to 3, and the remaining a, b, c and d groups represent CR or CR; or each of a, b, c and d is independently selected from CR or CR; each R and each R is independently selected from H, halo, -CR3, -OR, -COR, -SR, -S(O)tR (wherein t is 0, 1 or 2), -SCN, -N(R)2, -NRR, -NO2, -OC(O)R, -CO2R, -OCO2R, -CN, -NHC(O)R, -NHSO2R, -CONHR, -CONHCH2CH2OH, -NRCOOR, -SRC(O)OR, -SRN(R); n is 0 (zero), 1, 2, 3, 4, 5 or 6; T is -CO-; -SO-; -SO2-; or -CRR-; Z represents alkyl, aryl, aralkyl, heteroalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, -OR, -SR, -CRR, -NRR, formulae (i), (ii), (iii), (iv), (v) and (vi). Pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.

N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists

Compounds represented by Formula (I): 1or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.