1724-67-0 Usage
Description
2-(pyridin-4-yl)-1H-benzo[d]imidazol-6-amine is a heterocyclic aromatic amine with the molecular formula C13H10N4. It features a benzimidazole ring fused to a pyridine ring, with an amine group attached to the benzimidazole ring at position 6. This chemical compound is commonly used as a building block in the synthesis of various pharmaceuticals and organic molecules due to its potential pharmacological activities. It is being studied for its potential use in the treatment of various diseases and disorders and has been reported to possess anti-inflammatory and antioxidant properties, making it a valuable compound in medicinal chemistry.
Uses
Used in Pharmaceutical Synthesis:
2-(pyridin-4-yl)-1H-benzo[d]imidazol-6-amine is used as a building block for the synthesis of various pharmaceuticals and organic molecules. Its unique structure and pharmacological properties make it a promising candidate for the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-(pyridin-4-yl)-1H-benzo[d]imidazol-6-amine is used as a compound of interest for studying its potential use in the treatment of various diseases and disorders. Its anti-inflammatory and antioxidant properties are being investigated for their potential therapeutic benefits.
Used in Drug Development:
2-(pyridin-4-yl)-1H-benzo[d]imidazol-6-amine is utilized in drug development as a starting material or intermediate for the creation of new pharmaceuticals. Its heterocyclic structure and potential pharmacological activities make it a valuable component in the design and synthesis of novel therapeutic agents.
Used in Antioxidant and Anti-inflammatory Applications:
Due to its reported antioxidant and anti-inflammatory properties, 2-(pyridin-4-yl)-1H-benzo[d]imidazol-6-amine is being explored for its potential use in the development of treatments for conditions associated with oxidative stress and inflammation. Its ability to modulate these processes may contribute to the prevention or management of various diseases and disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 1724-67-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,2 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1724-67:
(6*1)+(5*7)+(4*2)+(3*4)+(2*6)+(1*7)=80
80 % 10 = 0
So 1724-67-0 is a valid CAS Registry Number.
1724-67-0Relevant articles and documents
BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS
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Page/Page column 59; 62, (2018/04/20)
The invention relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing said compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading t
Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5′-monophosphate dehydrogenase
Gorla, Suresh Kumar,Kavitha, Mandapati,Zhang, Minjia,Chin, James En Wai,Liu, Xiaoping,Striepen, Boris,Makowska-Grzyska, Magdalena,Kim, Youngchang,Joachimiak, Andrzej,Hedstrom, Lizbeth,Cuny, Gregory D.
, p. 4028 - 4043 (2013/06/27)
Cryptosporidium parvum is an enteric protozoan parasite that has emerged as a major cause of diarrhea, malnutrition, and gastroenteritis and poses a potential bioterrorism threat. C. parvum synthesizes guanine nucleotides from host adenosine in a streamlined pathway that relies on inosine 5′-monophosphate dehydrogenase (IMPDH). We have previously identified several parasite-selective C. parvum IMPDH (CpIMPDH) inhibitors by high-throughput screening. In this paper, we report the structure-activity relationship (SAR) for a series of benzoxazole derivatives with many compounds demonstrating CpIMPDH IC50 values in the nanomolar range and >500-fold selectivity over human IMPDH (hIMPDH). Unlike previously reported CpIMPDH inhibitors, these compounds are competitive inhibitors versus NAD +. The SAR study reveals that pyridine and other small heteroaromatic substituents are required at the 2-position of the benzoxazole for potent inhibitory activity. In addition, several other SAR conclusions are highlighted with regard to the benzoxazole and the amide portion of the inhibitor, including preferred stereochemistry. An X-ray crystal structure of a representative E·IMP·inhibitor complex is also presented. Overall, the secondary amine derivative 15a demonstrated excellent CpIMPDH inhibitory activity (IC 50 = 0.5 ± 0.1 nM) and moderate stability (t1/2 = 44 min) in mouse liver microsomes. Compound 73, the racemic version of 15a, also displayed superb antiparasitic activity in a Toxoplasma gondii strain that relies on CpIMPDH (EC50 = 20 ± 20 nM), and selectivity versus a wild-type T. gondii strain (200-fold). No toxicity was observed (LD 50 > 50 μM) against a panel of four mammalian cells lines.
