172470-05-2

Basic information

• Product Name: 4-[(3,5-dimethylphenyl)sulfanyl]-5-ethyl-6-methylpyridin-2(1H)-one
• Synonyms: 2(1H)-Pyridinone, 4-((3,5-dimethylphenyl)thio)-5-ethyl-6-methyl-; 2(1H)-Pyridinone, 4-[(3,5-dimethylphenyl)thio]-5-ethyl-6-methyl-; 2-pyridinol, 4-[(3,5-dimethylphenyl)thio]-5-ethyl-6-methyl-; 4-[(3,5-dimethylphenyl)sulfanyl]-5-ethyl-6-methylpyridin-2-ol
• CAS NO: 172470-05-2
• Molecular Formula: C₁₆H₁₉NOS
• Molecular Weight: 273.3932
• Mol File: 172470-05-2.mol

Chemical Properties

• Boiling Point: 440.6°C at 760 mmHg
• Flash Point: 220.3°C
• Density: 1.14g/cm³
• Vapor Pressure: 5.81E-08mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: 4-[(3,5-dimethylphenyl)sulfanyl]-5-ethyl-6-methylpyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(3,5-dimethylphenyl)sulfanyl]-5-ethyl-6-methylpyridin-2(1H)-one(172470-05-2)
• EPA Substance Registry System: 4-[(3,5-dimethylphenyl)sulfanyl]-5-ethyl-6-methylpyridin-2(1H)-one(172470-05-2)

Safety Data

• Hazardous Substances Data: 172470-05-2(Hazardous Substances Data)

Upstream product

• 172469-91-9 5-ethyl-6-methyl-3-carbethoxy-4-(3', 5'-dimethylphenyl)thio-pyridin-2(1H)-one 
• 42805-39-0 ethyl (Z)-3-amino-2-ethyl-but-2-enoate 
• 607-97-6 ethyl 2-ethyl-3-oxobutanoate 
• 172470-04-1 ethyl 5-ethyl-4-hydroxy-6-methyl-2-oxo-1H-pyridine-3-carboxylate 
• 172469-74-8 4-chloro-5-ethyl-6-methyl-3-carbethoxypyridin-2(1H)-one 

Relevant articles and documents

4-Aryl-thio-pyridin-2(1H)-ones, medicines containing them and their uses in the treatment of illnesses linked to HIV

PCT No. PCT/FR96/01204 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Jul. 30, 1996 PCT Pub. No. WO97/05113 PCT Pub. Date Feb. 13, 1997Compounds of formula (3) in which: R1 and R2 independently represent an atom of hydrogen, an aliphatic group or an alkyloxyalkyl group in which the alkyl chains are from C1 to C4 or together form an aromatic ring; R3 represents: an atom of hydrogen, or an NHR5 group in which R5 represents an atom of hydrogen or a COR6 group in which R6 is an aliphatic or aromatic group, or an NO2 group or a COOR7 group in which R7 is an aliphatic group, R4 represents a phenyl or heterocyclic group. These compounds can be used in the treatment of illnesses linked to the HIV virus.

A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors

4-(Arylthio)-pyridin-2(1H)-ones variously substituted in their 3-, 5-, and 6-positions have been synthesized as a new series of 1-[(2- hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)-pyridinone hybrid molecules. Biological studies revealed that some of them show potent HIV-1 specific reverse transcriptase inhibitory properties. Compounds 16 and 7c, the most active ones, inhibit the replication of HIV-1 at 3 and 6 nM, respectively.