172472-68-3

Upstream product

• 2524-49-4 3-butene-1-amine 
• 100-52-7 benzaldehyde 
• 113738-20-8 4-azido-1-butene 

Downstream Products

• 910562-04-8 meso-1-(but-3-enyl)-2,6-diphenylpiperidin-4-one 
• 17150-62-8 N-benzyl-3-butenylamine 
• 1400677-27-1 (S)-3-amino-1-benzylazocan-2-one trifluoroacetate 

Relevant academic research and scientific papers

SUBSTITUTED ADIPIC ACID AMIDES AND USES THEREOF

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein A is a five to eight membered monocyclic or a nine to twelve membered bicyclic heterocyclic ring, as further defined herein; Y is S, CH2, or CH; Z is CH or N; R7 and R9 are hydrogen or (C1-C6)alkyl; R2 is (C1 C6)alkoxy, OH, CN, (C1-C6)alkyl, halogen, or CF3; r and s are 0, 1, or 2; and R1 and R3 are as further defined herein. These compounds are agonists, partial agonists and/or modulators of the NPY4 receptor and may be used for the treatment and prophylaxis of obesity, food intake, and other diseases and conditions modulated by the NPY4 receptor.

Ugi/xanthate cyclizations as a radical route to lactam scaffolds

The combination of Ugi reaction and xanthate radical cyclization onto alkenes allows an easy access to various highly functionalized heterocycles. The addition of chloroacetic acid to primary amines, aldehydes and isocyanides in methanol followed by the t

Cyclizations of substituted benzylidene-3-alkenylamines: Synthesis of the tricyclic core of the martinellines

The martinellines (1 and 2) are natural products that possess both interesting biological activity and chemical structure. During the investigation of a hetero Diels-Alder route to these molecules, alternate Lewis acid-dependent cyclizations of (2'-amino-N'-tert-butoxycarbonyl-5'- chlorobenzylidene)-3-butenylamine (10) were observed. The reaction of a variety of imines with TMSOTf or TiCl4 led to the formation of different heterocycles including iminodibenzo[b,f][1,5]diazocines, hexahydropyrido[1,2- c]quinazolin-6-ones, tetrahydropyrrolo[1,2-c]quinazolin-5-ones, 2- arylpiperidines, and 2-arylpyrrolidines. Tetrahydropyrrolo[1,2-c]quinazolin- 5-one 54, obtained via this new methodology, was used as an intermediate in the synthesis of the tricyclic ring system (65) of the martinellines.