17249-62-6

Basic information

• Product Name: (5-HYDROXY-1-BENZOFURAN-3-YL)(PHENYL)METHANONE
• Synonyms: (5-HYDROXY-1-BENZOFURAN-3-YL)(PHENYL)METHANONE;(5-Hydroxybenzofuran-3-yl)(phenyl)Methanone
• CAS NO: 17249-62-6
• Molecular Formula: C₁₅H₁₀O₃
• Molecular Weight: 238.24
• Mol File: 17249-62-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 182-184°C
• Boiling Point: 417.1°Cat760mmHg
• Flash Point: 206.1°C
• Appearance: /
• Density: 1.302g/cm³
• Vapor Pressure: 1.5E-07mmHg at 25°C
• Refractive Index: 1.666
• PKA: 8.35±0.40(Predicted)
• CAS DataBase Reference: (5-HYDROXY-1-BENZOFURAN-3-YL)(PHENYL)METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (5-HYDROXY-1-BENZOFURAN-3-YL)(PHENYL)METHANONE(17249-62-6)
• EPA Substance Registry System: (5-HYDROXY-1-BENZOFURAN-3-YL)(PHENYL)METHANONE(17249-62-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 17249-62-6(Hazardous Substances Data)

Usage

General Description

(5-Hydroxy-1-benzofuran-3-yl)(phenyl)methanone is a chemical compound composed of two core chemical structures, benzofuran and phenyl. Benzofuran has a bicyclic structure and is composed of a fused benzene and furan ring. Its derivative, 5-Hydroxy-1-benzofuran-3-yl, suggests an additional hydroxyl (OH) group in the 5th position. On the other hand, phenyl is a functional group characterised by a cyclic ring of six carbon atoms, often functioning as a base for more complex compounds. Methanone indicates the presence of a carbonyl group (C=O) attached to an alkyl group. Known applications, properties, and risks of this compound depend on further specifics, including its stereochemistry and any additional chemical groups present. It doesn’t appear to be widely studied or commonly used in industry or academia currently.

InChI:InChI=1/C15H10O3/c16-11-6-7-14-12(8-11)13(9-18-14)15(17)10-4-2-1-3-5-10/h1-9,16H

Upstream product

• 98-86-2 acetophenone 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 106-51-4 p-benzoquinone 

Downstream Products

• 344868-28-6 Acetic acid 3-benzoyl-benzofuran-5-yl ester 
• 1254339-02-0 3-benzoyl-benzofuran-4,5-dione 
• 19303-49-2 (5-methoxy-benzofuran-3-yl)-phenyl-methanone 
• 1251913-23-1 methyl 2-(3-benzoylbenzofuran-5-yloxy)acetate 
• 1441074-91-4 ethyl 2-(3-benzoylbenzofuran-5-yloxy)acetate 
• 1442656-13-4 2-(3-phenyl-1H-pyrazol-4-yl)benzene-1,4-diol 
• 1442656-18-9 ethyl 2-[4-hydroxy-3-(3-phenyl-1H-pyrazol-4-yl)phenoxy]acetate 
• 1442656-17-8 methyl 2-[4-hydroxy-3-(3-phenyl-1H-pyrazol-4-yl)phenoxy]acetate 
• 1442656-16-7 C₁₆H₁₄N₂O₂ 
• 1001434-11-2 3-benzoyl-5-benzofuranyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside 
• 88673-87-4 (5-Hydroxy-4,6-dinitro-benzofuran-3-yl)-phenyl-methanone 
• 88673-82-9 (4,6-Dibromo-5-hydroxy-benzofuran-3-yl)-phenyl-methanone 
• 88673-79-4 (4-Bromo-5-hydroxy-benzofuran-3-yl)-phenyl-methanone 
• 88673-85-2 (4-Chloro-5-hydroxy-benzofuran-3-yl)-phenyl-methanone 

Relevant articles and documents

Amberlyst-15 in PEG-400: Green synthesis of 3-benzoyl-5-hydroxy benzofuran and naphtho[1,2-b]furan derivatives at room temperature

Background: Oxygen heterocycles exhibit diverse biological and pharmacological activities. In particular, benzofurans are available in a wide number of natural products and have drawn considerable attention over the last few years due to their profound physiological and biological properties. The aim of this paper describes a green methodology to synthesize this potent molecule with high selectivity by using ionic resin in PEG at room temperature. Methods: The methodology is very simple and easily accessible at room temperature. It uses low catalyst loadings and is recycled subsequently. In addition, detailed experimental procedure for the selected compounds including the spectral data are provided. Results: Among the various ionic resins attempted, Amberlyst-15 in PEG-400 was the choice of selection for the synthesis of 3-benzoyl-5-hydroxy benzofuran and naphtho[1,2-b]furan derivatives at room temperature in an environmentally friendly method. This catalyst system resulted in excellent yields in short reaction times and high selectivity. Conclusion: We have developed a green highly efficient and environmentally friendly protocol for the facile synthesis of 3-benzoyl-5-hydroxy benzofuran and naphtho[1,2-b]furan derivatives at room temperature in high yields (>90-95%) using nontoxic and inexpensive ion exchange resin Amberlyst-15. The notable advantages of the catalyst approach enables the reactions with high selectivity, short reactions time and excellent yields without generating any waste and was reused.

BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS

The instant invention provides novel benzofuran-4,5-diones and pharmaceutical compositions thereof useful for inhibiting PDF and for treating proliferative and infectious diseases. Compounds may be selective for eukaryotic (e.g., human) PDF or prokaryotic PDF