172498-89-4

Usage

Uses

Used in Organic Synthesis:
5-Hydroxylmethyl-1-N-Trityl-Imidazole is used as a reagent in organic synthesis for its ability to participate in a variety of chemical reactions. The hydroxylmethyl group allows for the formation of new bonds and the trityl group provides stability during these processes.
Used in Pharmaceutical Drug Development:
In the pharmaceutical industry, 5-Hydroxylmethyl-1-N-Trityl-Imidazole is used as a building block in the development of new drugs. Its unique structure and reactivity make it a valuable component in the synthesis of potential therapeutic agents.
Used in Biological Experimentation:
5-Hydroxylmethyl-1-N-Trityl-Imidazole is employed as a research tool in biological experimentation. Its properties can be utilized to study various biological processes and interactions, contributing to a better understanding of molecular biology and potential drug targets.
Used in Industrial Chemical Processes:
5-HYDROXYLMETHYL-1-N-TRITYL-IMIDAZOLE is also used in industrial chemical processes where its reactivity and protective trityl group are advantageous for the production of various chemical products. Its versatility in participating in chemical reactions makes it a valuable asset in the chemical manufacturing industry.

InChI:InChI=1/C23H20N2O/c26-17-22-16-24-18-25(22)23(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-16,18,26H,17H2

Upstream product

• 822-55-9 (1H-imidazol-4-yl)methanol 
• 76-83-5 trityl chloride 

Downstream Products

• 1438409-81-4 C₃₅H₂₉N₃O₃S 
• 163009-48-1 diphenylmethyl 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(3-tritylimidazol-4-yl)methylthio]-3-cephem-4-carboxylate 
• 339162-41-3 1-trityl-4-benzoylthiomethylimidazole 

Relevant academic research and scientific papers

Imidazole-containing inhibitors of farnesyl protein transferase

Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of the formula their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs, and solvates, wherein:, G is G1 is G2 is or -NR10-CH(Q1)-;, J, K and L are each, independently, N, NR9, O, S or CR10 with the provisos that only one of the groups J, K and L can be O or S, and at least one of the groups J or L must be N, NR9, O or S to form a fused five-membered heteroring; the bond between J and K or K and L may also form one side of a phenyl ring fused to the fused five-membered heteroring;, Q is aryl;, Q1, A1 and A2 are each, independently, H, alkyl, substituted alkyl, phenyl or substituted phenyl;, G3 is R11, -C(O)OR11, -C(O)NR11R12, 5-tetrazolyl, -C(O)N(R13)OR11, -C(O)NHSO2R14 or -CH2OR11;, G4 is attached at the 1, 2, 4 or 5 position and optionally substituted, at any of the available position or positions on the ring, with halo, alkyl or substituted alkyl having 1 to 20 carbon atoms, alkoxy, aryl, aralkyl, hydroxy, alkanoyl, alkanoyloxy, amino, alkylamino, dialkylamino, alkanoylamino, thiol, alkylthio, alkylthiono, alkylsulfonyl, sulfonamido, nitro, cyano, carboxy, carbamyl, N-hydroxycarbamyl, N-alkylcarbamyl, N-dialkylcarbamyl, alkoxycarbonyl, phenyl, substituted phenyl, or a combinaton of these groups;, Y and Z are each, independently, -CH2- or -C(O)-;, R1 - R14 are each, independently, H or alkyl having 1 to 20 carbon atoms;, R7, R8 and R14 may also be aryl or aralkyl, and R3, R9, R11, R12 and R13 may also be aralkyl;, m, n and p are each, independently, 0 or an integer from 1 to 2;, q is 0 or an integer from 1 to 4; and, the dotted line represents an optional double bond.