172498-89-4

Basic information

• Product Name: 5-HYDROXYLMETHYL-1-N-TRITYL-IMIDAZOLE
• Synonyms: (1-trityl-1H-imidazol-5-yl)methanol;REF DUPL: 5-Hydroxylmethyl-1-N-trityl-imidazole;1H-Imidazole-5-methanol, 1-(triphenylmethyl)-
• CAS NO: 172498-89-4
• Molecular Formula: C₂₃H₂₀N₂O
• Molecular Weight: 340.424
• Mol File: 172498-89-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 516.1°C at 760 mmHg
• Flash Point: 265.9°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 1.77E-11mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 5-HYDROXYLMETHYL-1-N-TRITYL-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDROXYLMETHYL-1-N-TRITYL-IMIDAZOLE(172498-89-4)
• EPA Substance Registry System: 5-HYDROXYLMETHYL-1-N-TRITYL-IMIDAZOLE(172498-89-4)

Safety Data

• Hazardous Substances Data: 172498-89-4(Hazardous Substances Data)

Usage

General Description

5-Hydroxylmethyl-1-N-Trityl-Imidazole is a chemical compound that exhibits properties utilized in organic synthesis and pharmaceutical drug development. As an imidazole derivative, it typically features a five-membered planar ring system that includes two nitrogen atoms, making it a part of the larger class of heterocyclic compounds. Its molecular structure is further modified by a trityl group, a triphenylmethyl component that serves as a protective group in chemical reactions. Moreover, the hydroxylmethyl component contributes to the compound's reactivity, enabling it to participate in diverse chemical reactions. This makes 5-Hydroxylmethyl-1-N-Trityl-Imidazole valuable in a wide range of applications, from biological experimentation to industrial chemical processes.

InChI:InChI=1/C23H20N2O/c26-17-22-16-24-18-25(22)23(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-16,18,26H,17H2

Upstream product

• 822-55-9 (1H-imidazol-4-yl)methanol 
• 76-83-5 trityl chloride 

Downstream Products

• 1438409-81-4 C₃₅H₂₉N₃O₃S 
• 163009-48-1 diphenylmethyl 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(3-tritylimidazol-4-yl)methylthio]-3-cephem-4-carboxylate 
• 339162-41-3 1-trityl-4-benzoylthiomethylimidazole 

Relevant articles and documents

Imidazole-containing inhibitors of farnesyl protein transferase

Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of the formula their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs, and solvates, wherein:, G is G1 is G2 is or -NR10-CH(Q1)-;, J, K and L are each, independently, N, NR9, O, S or CR10 with the provisos that only one of the groups J, K and L can be O or S, and at least one of the groups J or L must be N, NR9, O or S to form a fused five-membered heteroring; the bond between J and K or K and L may also form one side of a phenyl ring fused to the fused five-membered heteroring;, Q is aryl;, Q1, A1 and A2 are each, independently, H, alkyl, substituted alkyl, phenyl or substituted phenyl;, G3 is R11, -C(O)OR11, -C(O)NR11R12, 5-tetrazolyl, -C(O)N(R13)OR11, -C(O)NHSO2R14 or -CH2OR11;, G4 is attached at the 1, 2, 4 or 5 position and optionally substituted, at any of the available position or positions on the ring, with halo, alkyl or substituted alkyl having 1 to 20 carbon atoms, alkoxy, aryl, aralkyl, hydroxy, alkanoyl, alkanoyloxy, amino, alkylamino, dialkylamino, alkanoylamino, thiol, alkylthio, alkylthiono, alkylsulfonyl, sulfonamido, nitro, cyano, carboxy, carbamyl, N-hydroxycarbamyl, N-alkylcarbamyl, N-dialkylcarbamyl, alkoxycarbonyl, phenyl, substituted phenyl, or a combinaton of these groups;, Y and Z are each, independently, -CH2- or -C(O)-;, R1 - R14 are each, independently, H or alkyl having 1 to 20 carbon atoms;, R7, R8 and R14 may also be aryl or aralkyl, and R3, R9, R11, R12 and R13 may also be aralkyl;, m, n and p are each, independently, 0 or an integer from 1 to 2;, q is 0 or an integer from 1 to 4; and, the dotted line represents an optional double bond.