1725-89-9Relevant academic research and scientific papers
Synthesis and screening of in vitro antibacterial and enzyme inhibitory activity of N,N-disubstituted 4-chlorobenzenesulfonamides
Aziz-ur-Rehman,Nafeesa, Khadija,Abbasi, Muhammad Athar,Nadeem, Sohail,Khan, Khalid Mohammed,Ahmad, Irshad,Afzal, Saira
, p. 1096 - 1104 (2015/01/30)
Sulfonamide, pharmacologically important class of compounds, is of significant interest for scientists due to increased resistance in microbes against the existing drug constituents. So the aim of following research work was to synthesize new more effecti
Synthesis, structural analysis and pharmacological screening of chlorinated sulfonamides
Aziz-Ur-Rehman,Tahir, Saif-Ur-Rehman,Abbasi, Muhammad Athar,Rasool, Shahid,Siddiqa, Asia,Awais-Ur-Rehman,Muhammad, Ali,Sharif, Ahsan
, p. 9000 - 9004 (2013/11/19)
In present work, a facile and environmentally benign series of chlorinated sulfonamides was synthesized and screened against different enzymes. These were geared up by the coupling of 4-chlorobenzenesulfonyl chloride (1) with different substituted aromatic amines (2a-l) under dynamic pH control in aqueous media to form various chlorinated sulfonamides (3a-l). The synthesized chlorinated sulfonamides were spectrally characterized like 1H NMR, IR and EI-MS. The bioactivity of all the synthesized compounds were evaluated against urease, butyrylcholinesterase (BChE) and lipoxygenase (LOX) enzymes and found to be having talented activity against butyrylcholinesterase enzyme.
