172587-58-5

Upstream product

• 172587-56-3 Benzoic acid (2R,4R)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester 
• 170210-39-6 (2R,4R)-(+)-<2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl>methyl benzoate 
• 124-63-0 methanesulfonyl chloride 
• 172587-57-4 (2R,4S)-(+)-2-(2,4-dichlorophenyl)-2-<(1H-1,2,4-triazol-1-yl)methyl>-1,3-dioxolane-4-methanol 

Downstream Products

• 172587-59-6 terconazole 
• 214117-53-0 (2R,4S)-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-piperazine 

Relevant academic research and scientific papers

Stereoselective Syntheses of (+)- and (-)-Terconazole

The recently described cis-benzoates (2R,4R)- and (2S,4S)-2 were transformed into (+)- and (-)-terconazole, respectively by reaction with 1H-1,2,4-triazole followed by hydrolysis to give alcohols (+)- and (-)-3 which were mesylated and reacted with phenol