172604-01-2Relevant academic research and scientific papers
Design and Synthesis of Conformationally Constrained Analogues of 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as Potent Inhibitors of cAMP-Specific Phosphodiesterase
Brackeen, Marcus F.,Cowan, David J.,Stafford, Jeffrey A.,Schoenen, Frank J.,Veal, James M.,et al.
, p. 4848 - 4854 (1995)
The synthesis and bilogical evaluation of cAMP-specific phosphodiesterase (PDE IV) inhibitors is described.The PDE IV inhibitor 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724, 2) was used as a template from which to design a set of rigid oxazo
