Design and Synthesis of Conformationally Constrained Analogues of 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as Potent Inhibitors of cAMP-Specific Phosphodiesterase

DOI: 10.1021/jm00024a012

Source and publish data:

Journal of Medicinal Chemistry p. 4848 - 4854 (1995)

Update date:2022-07-29

Topics:

Authors:

Brackeen, Marcus F.

Cowan, David J.

Stafford, Jeffrey A.

Schoenen, Frank J.

Veal, James M.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00024a012

The synthesis and bilogical evaluation of cAMP-specific phosphodiesterase (PDE IV) inhibitors is described.The PDE IV inhibitor 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724, 2) was used as a template from which to design a set of rigid oxazo

Full text of DOI:10.1021/jm00024a012

Products guided by the article

Product name:2-(cyclopentyloxy)-4-(2,2-dibromovinyl)-1-methoxybenzene

Cas No:172604-01-2

R&D Labs maybe for 172604-01-2

Shanghai Hongbang Medical Technology CO.,. Ltd

Contact:13671516988 /18917636693

Address:Room1, No67 Building, Yongde Road369, Wujing Town, Minhang Districy, Shanghai CIty, China.
JIN TAN CHENG'EN CHEMICAL CO.,LTD.

Contact:86-519-82116250

Address:NO.102，village Dongfang，conomic development zone
Shandong Loyal Chemical industrial Co.,Ltd

Contact:0533-7451788

Address:Linzi Chemical Industrial Park, Zibo, Shandong Province
Shijiazhuang Haotian Chemical Co., Ltd.

Contact:86-311-85044374

Address:293 Donggang Road
Nantong Auxin Electronic Technology Co., LTD

Contact:86-513-88760026

Address:NO.5-1, Aoxin Road, Haian Hi-tech Development Zone, Jiangsu Province, China

Relevant to this article

Polyethylene glycol (PEG-400) as an efficient and recyclable reaction medium for the one-pot synthesis of n-substituted azepines under catalyst-free conditions

Doi:10.1055/s-0031-1289542
(2011)
Sodium oximates as starting materials for the synthesis of half-sandwich-type arene( oximato) and arene( azavinylidene) osmium complexes

Doi:10.1016/0022-328X(95)06010-T
(1996)
Synthesis and antitumor activity of conjugates of 5-Fluorouracil and emodin

Doi:10.1016/j.ejmech.2011.10.050
(2012)
Selective dehydrogenative silylation-hydrogenation reaction of divinyldisiloxane with hydrosilane catalyzed by an iron complex

Doi:10.1021/ja209436s
(2012)
Ligand-free, PdCl₂(PPh₃)₂ catalyzed, microwaveassisted Suzuki coupling of 1-chloro-3-phenylisoquinoline in the synthesis of diversified 1,3-disubstituted isoquinolines

Doi:10.1007/s11164-011-0350-7
(2012)
Synthesis of steroidal quinones and hydroquinones from bile acids by Barton radical decarboxylation and benzoquinone addition. Studies on their cytotoxic and antifungal activities

Doi:10.1016/j.steroids.2011.09.012
(2012)

Article Doi