Journal of Medicinal Chemistry p. 4848 - 4854 (1995)
Update date:2022-07-29
Topics:
Brackeen, Marcus F.
Cowan, David J.
Stafford, Jeffrey A.
Schoenen, Frank J.
Veal, James M.
et al.
The synthesis and bilogical evaluation of cAMP-specific phosphodiesterase (PDE IV) inhibitors is described.The PDE IV inhibitor 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724, 2) was used as a template from which to design a set of rigid oxazo
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