Design and Synthesis of Conformationally Constrained Analogues of 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as Potent Inhibitors of cAMP-Specific Phosphodiesterase

DOI: 10.1021/jm00024a012

Source and publish data:

Journal of Medicinal Chemistry p. 4848 - 4854 (1995)

Update date:2022-07-29

Topics:

Authors:

Brackeen, Marcus F.

Cowan, David J.

Stafford, Jeffrey A.

Schoenen, Frank J.

Veal, James M.

et al. et al.

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Article abstract of DOI:10.1021/jm00024a012

The synthesis and bilogical evaluation of cAMP-specific phosphodiesterase (PDE IV) inhibitors is described.The PDE IV inhibitor 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724, 2) was used as a template from which to design a set of rigid oxazo

Full text of DOI:10.1021/jm00024a012

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Product name:2-(cyclopentyloxy)-4-(2,2-dibromovinyl)-1-methoxybenzene

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