172607-47-5

Upstream product

• 133178-71-9 2-(4-amino-3-iodophenyl)acetic acid 
• 101395-32-8 N'-(5-aminopentyl)-N-(4-methoxybenzyl)-N'-methyl-N-2-pyridinyl-1,2-ethanediamine 
• 172607-50-0 (4-{[5-({2-[(4-Methoxy-benzyl)-pyridin-2-yl-amino]-ethyl}-methyl-amino)-pentylcarbamoyl]-methyl}-phenyl)-carbamic acid tert-butyl ester 
• 81196-09-0 2-(4-(tert-butoxycarbonylamino)phenyl)acetic acid 

Relevant academic research and scientific papers

Synthesis and authentication of iodoazidophenpyramine, a photoaffinity reporter ligand previously used for histamine H1-receptor labelling

The synthesis is described of aminophenpyramine (7) (N-{5-[2-(4-aminophenyl)ethanamido]pentanyl}-N'-(4-methoxybenzyl)-N- methyl-N'-(2-pyridinyl)-1,2-ethandiamine), its monoiodo- and diiodo-derivatives (8 and 9), and iodoazidophenpyramine (1). The last compound is synthesised by two different routes to confirm the identity of the [125I]iodinated ligand previously made only in solution and used for characterisation of the hitamine H1-receptor protein. The procedures employ the novel intermediates 4-amino-3-iodo-phenylacetic acid (11) and 4-azido-3-iodo-phenylacetic acid (13). They have general applicability to the synthesis of non-radioactive iodinated photoaffinity receptor ligands which may be required for chemical authentication of the corresponding radiolabelled compounds.