133178-71-9

Usage

Uses

Used in Pharmaceutical Synthesis:
(4-Amino-3-iodophenyl)acetic acid is used as a key intermediate in the production of various pharmaceuticals due to its unique chemical structure and reactivity. Its presence in the synthesis process allows for the creation of a wide range of biologically active compounds with potential therapeutic applications.
Used in Thyroid Hormone Production:
4-AIPAA is utilized in the production of thyroid hormones, which are essential for regulating metabolism, growth, and development in the human body. The iodine atom in 4-AIPAA plays a crucial role in this application, as iodine is a key component of thyroid hormones.
Used in Anti-Inflammatory Applications:
(4-Amino-3-iodophenyl)acetic acid is used as an anti-inflammatory agent for its potential to modulate inflammatory processes in the body. The presence of the amino group may contribute to its anti-inflammatory properties, although further research is needed to fully understand its mechanism of action.
Used in Anticancer Applications:
4-AIPAA has been studied for its potential anti-cancer properties, with research indicating that it may have the ability to inhibit the growth and proliferation of cancer cells. The exact mechanisms of its anti-cancer effects are still under investigation, but its unique chemical structure, including the iodine atom, may play a role in its activity against cancer.
Used in Radioiodine Therapy for Thyroid Cancer:
The presence of the iodine atom in 4-AIPAA makes it suitable for use in radioiodine therapy for thyroid cancer. Radioiodine therapy involves the use of radioactive iodine isotopes to target and destroy thyroid cancer cells. 4-AIPAA could potentially be used to deliver these isotopes to cancerous tissues, enhancing the effectiveness of the treatment.

Upstream product

• 1197-55-3 4-aminophenylacetic acid 
• 5438-70-0 ethyl (4-amino-3,5-dibromophenyl)acetate 
• 405267-73-4 (4-amino-3-iodophenyl)acetic acid ethyl ester 

Downstream Products

• 161084-81-7 (4-azido-3-iodophenyl)-acetic acid 
• 172607-47-5 Iodoaminophenpyramine 
• 188111-63-9 (2-Methyl-benzothiazol-6-yl)-acetic acid methyl ester 
• 103261-69-4 2-methylbenzothiazole-6-acetic acid 
• 161084-83-9 (4-azido-3-iodophenyl)-acetic anhydride 

Relevant academic research and scientific papers

p--m-Azidophenyl Acetyl Acid, a Useful Reagent for the Synthesis of Radioactive Photoaffinity Ligands. Synthesis of Photoaffinity Labelling Ecdysones

The synthesis of -p-azidophenyl acetic acid and its use in the preparation of aryl azido photoaffinity labelled 20-hydroxyecdysone analogues is described.

HETEROCYCLIC DERIVATIVES AS RORGAMMA MODULATORS

The present invention provides novel compounds of formula (I) that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, fibrotic diseases, or cholestatic diseases.

Structure-activity studies for a novel series of N-(arylethyl)-N- (1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamines possessing dual 5- HT uptake inhibiting and α2-antagonistic activities

In search of an α2-antagonist/5-HT uptake inhibitor as a potential new class of antidepressant with a more rapid onset of action, compound 3 was prepared and observed to possess high affinity for the α2-receptor (K(i) = 6.71 nM) and

Synthesis and authentication of iodoazidophenpyramine, a photoaffinity reporter ligand previously used for histamine H1-receptor labelling

The synthesis is described of aminophenpyramine (7) (N-{5-[2-(4-aminophenyl)ethanamido]pentanyl}-N'-(4-methoxybenzyl)-N- methyl-N'-(2-pyridinyl)-1,2-ethandiamine), its monoiodo- and diiodo-derivatives (8 and 9), and iodoazidophenpyramine (1). The last compound is synthesised by two different routes to confirm the identity of the [125I]iodinated ligand previously made only in solution and used for characterisation of the hitamine H1-receptor protein. The procedures employ the novel intermediates 4-amino-3-iodo-phenylacetic acid (11) and 4-azido-3-iodo-phenylacetic acid (13). They have general applicability to the synthesis of non-radioactive iodinated photoaffinity receptor ligands which may be required for chemical authentication of the corresponding radiolabelled compounds.

Synthesis of iodo-aryl-azido adenosine analogs as affinity ligands for adenylyl cyclase

Potential affinity probes for adenylyl cyclase were synthesized that take advantage of the enzyme's sensitivity to 'P'-site-mediated inhibition by 2',5'-dideoxyadenosine analogs and its tolerance for large 3'-ribose substitutions. We report the synthesis