90503-06-3

Basic information

• Product Name: AzithroMycin N-Oxide
• Synonyms: Azithromycin N-Oxide (15 mg);(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-;Azithromycin EP Impurity L;Azithromycin 3-N-Oxide;Azithromycin Impurity V;Azithromycin Impurity L(BP)
• CAS NO: 90503-06-3
• Molecular Formula: C38H72N2O13
• Molecular Weight: 764.98388
• Product Categories: Chiral Reagents;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 90503-06-3.mol

Chemical Properties

• Appearance: /
• PKA: 12.51±0.60(Predicted)
• CAS DataBase Reference: AzithroMycin N-Oxide(CAS DataBase Reference)
• NIST Chemistry Reference: AzithroMycin N-Oxide(90503-06-3)
• EPA Substance Registry System: AzithroMycin N-Oxide(90503-06-3)

Safety Data

• Hazardous Substances Data: 90503-06-3(Hazardous Substances Data)

Upstream product

• 83905-01-5 Zithromax(R) 

Downstream Products

• 172617-84-4 (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)‐2‐ethyl‐3,4,10‐trihydroxy‐13‐{(2R,4R,5S,6S)‐5‐hydroxy‐4‐methoxy‐4,6‐dimethyl-tetrahydropyran‐2‐yloxy}‐11‐{(2S,3R,4S,6R)‐3‐hydroxy‐6‐methyl‐4‐methylamino-tetrahydropyran‐2‐yloxy}‐3,5,6,8,10,12,14‐heptamethyl‐1‐oxa‐6‐azacyclopentadecan‐15‐one 

Relevant articles and documents

Macrocyclic lactone impurity synthetic method

The invention relates to a method for preparing an azithromycin impurity I and an azithromycin impurity E. The method comprises the following steps: mixing azithromycin with a solvent, and adding the mixture into a compound which is shown as (I) in the description to perform a demethylation reaction, wherein R1 and R2 are respectively and independently methyl, ethyl, propyl, naphthenic group, a phenyl and p-methylphenyl. According to the method for preparing azithromycin impurity, the reaction is carried out under a mild condition; the method can be used for preparing the azithromycin impurity I and the azithromycin impurity E by controlling the amount of a reagent; the HPLC purity of the azithromycin impurities prepared by the method is 98 percent or more.

Derivatives of azithromycin

The invention relates to derivatives of azithromycin, processes for the manufacture thereof and pharmaceutical compositions thereof preferably together with azithromycin.

9A-AZALIDES WITH ANTI-INFLAMMATORY ACTIVITY

Macrolides with anti-inflammatory activity are described, and more particularly, 9a-azalides without cladinose in position 3 with anti-inflammatory activity, their pharmaceutically acceptable salts and pharmaceutical compositions that contain them as active principle.

BIFUNCTIONAL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME

The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and metho