17263-38-6Relevant articles and documents
Salivary aldehyde dehydrogenase: Activity towards aromatic aldehydes and comparison with recombinant ALDH3A1
Giebultowicz, Joanna,Wolinowska, Renata,Sztybor, Anna,Pietrzak, Monika,Wroczynski, Piotr,Wierzchowski, Jacek
, p. 2363 - 2372 (2009)
A series of aromatic aldehydes was examined as substrates for salivary aldehyde dehydrogenase (sALDH) and the recombinant ALDH3A1. Para-substituted benzaldehydes, cinnamic aldehyde and 2-naphthaldehydes were found to be excellent substrates, and kinetic p
Reactions of Carbonyl Compounds in Basic Solutions. Part 29. The Alkaline Hydrolysis of Unsaturated Lactones
Agnihotri, Kanwaljit,Bowden, Keith
, p. 1929 - 1946 (2007/10/03)
Rate coefficients have been measured for the alkaline hydrolysis of (E)-3-(substituted phenylmethylidene)-4,5-dihydrofuran-2(3H)-ones, (E)-3-(substituted phenylmethylidene)-3,4,5,6-tetrahydropyran-2(3H)-ones, (E)-5-(substituted phenyl)-3-(substituted phenylmethylidene)furan-2(3H)-ones, (Z)-3-(substituted phenylmethylidene)isobenzofuran-1(3H)-ones, 4,6-diphenyl-2-pyrone and ethyl (E)-3-(substituted phenyl)prop-2-enoates in 70percent (v/v) dioxane-water at 30.0 deg C, as well as for the parent unsubstituted compounds at 45.0 and 60.0 deg C and in 70percent (v/v) dimethyl sulfoxide (DMSO) at 30.0 deg C.The enthalpies and entropies of activation have been evaluated.The effects of substitution have been assessed by means of the Hammett equation.The reaction constants, ρ, vary from ca. 1.5 to 0.7.Comparison with model esters indicates that the unsaturated lactones, except the 2-pyrone, are more reactive by factors of ca. 2 to 180.This effect is less than that observed for comparable saturated lactones.The reduction arises from resonance interactions between the lactone function and the unsaturated or aryl group which decrease the factors responsable for the greater reactivity of lactones.Reactivity-selectivity is not shown over the range of lactones studied.The lactones hydrolyse with rate determining attack by hydroxide anion at the carbonyl group, followed by rapid ring fission.The results are related to the stereochemical polar and steric factors controlling reactivity.
Kinetisch-spektroskopische Analyse von Folgereaktionen durch "Formale Integration"
Lachmann, Gabriele,Lachmann, Heinrich,Mauser, Heinz
, p. 9 - 18 (2007/10/02)
For kinetic analysis of first order consecutive or parallel reactions, which are composed of two linearly independent reaction steps (for example A -> B -> C), a linear regression method is derived.By this method absorbance-time measurements can be evaluated directly.In contrast to other methods absorbance-time curves at two different wavelengths are combined for evaluation.Starting concentrations, Ainfinite-values, molar absorptivities etc. do not need to be known.The time intervals need not be equally spaced.For any evaluation a mini-computer is sufficient.By means of the "Formal Integration" method both eigenvalues of the kinetic matrix and the Ainfinite-values may be calculated.In the most simple consecutive reaction A -> B -> C the eigenvalues are identical with the rate constants.The procedure can also be used for other spectroscopic techniques, if an equation corresponding to Beer-Lambert's law exists (for example in CD-, ORD-, IR-spectrometry).The hydrolysis of trans cinnamic acid p-nitrophenylester catalyzed by imidazole is used as an experimental application to demonstrate the advantages of the "Formal Integration" method, which is also compared with other methods. - Keywords: Kinetic analysis / First order consecutive reactions / Formal integration / Spectrometry / Cinnamic acid p-nitrophenylester
