172681-48-0Relevant articles and documents
Halogenated Phenols for Diagnostics, Antioxidant Protection and Drug Delivery
-
Paragraph 0259, (2018/05/16)
The present invention provides compositions and methods for the targeted delivery, release and/or formation of a drug compound at a target site(s) within the body of an individual, such as a diseased and/or inflamed tissue in the body of the individual. These compositions may comprise a halogenated phenol ring cleavably linked to a core structure of a drug compound. Due to the variety of substituents that may be utilized in forming the different types of linkages, numerous examples of drug compounds linked to a halogenated phenol ring are proposed. The present invention further provides compositions comprising halogenated phenol starting compounds that do not undergo cleavage during a dehalogenation reaction to form a drug compound in a targeted tissue when administered to an individual. Methods of administering these non-cleaving compounds are further provided.
Synthesis of polycyclic heterocycles via a one-pot ortho alkylation/direct heteroarylation sequence
Martins, Andrew,Alberico, Dino,Lautens, Mark
, p. 4827 - 4829 (2007/10/03)
(Chemical Equation Presented) Polycyclic thiophenes and furans were synthesized using a one-pot ortho alkylation/direct heteroarylation reaction sequence. Under the optimized reaction conditions, aryl iodides were coupled with 3-(bromoalkyl)thiophenes or
