17269-81-7

Basic information

• Product Name: Phenol, 2-bromo-6-(2-propenyl)-
• CAS NO: 17269-81-7
• Molecular Formula: C9H9BrO
• Molecular Weight: 213.074
• Mol File: 17269-81-7.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Phenol, 2-bromo-6-(2-propenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-bromo-6-(2-propenyl)-(17269-81-7)
• EPA Substance Registry System: Phenol, 2-bromo-6-(2-propenyl)-(17269-81-7)

Safety Data

• Hazardous Substances Data: 17269-81-7(Hazardous Substances Data)

Upstream product

• 1745-81-9 o-Allylphenol 
• 95-56-7 2-hydroxybromobenzene 
• 106-95-6 allyl bromide 
• 60333-75-7 O-allyl-2-bromophenol 

Downstream Products

• 88275-72-3 3-Brom-2-methoxy-1-(2-propenyl)benzol 
• 852110-52-2 (7-bromo-2,3-dihydro-1-benzofuran-2-yl)methyl-4-methylbenzenesulfonate 
• 413599-93-6 1-allyl-3-bromo-2-methoxymethoxybenzene 
• 1378871-35-2 3-allyl-2-methoxymethoxy-1-phenylboronic acid 
• 88275-87-0 3-bromo-2-methyloxybenzaldehyde 
• 876922-79-1 (3-bromo-2-hydroxyphenyl)acetaldehyde 
• 913630-44-1 1-allyl-2-benzyloxy-3-bromo-benzene 
• 88295-03-8 (1S,2R,3R,4R)-2-{2-Methoxy-3-[3-(tetrahydro-pyran-2-yloxy)-propyl]-benzyl}-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanol 
• 88275-76-7 (1R,2R,3R,4R)-2-{2-Methoxy-3-[3-(tetrahydro-pyran-2-yloxy)-propyl]-benzyl}-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanol 
• 93381-41-0 2-{(1R,2R,3R,5S)-5-Hydroxy-3-(tetrahydro-pyran-2-yloxy)-2-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl}-6-[3-(tetrahydro-pyran-2-yloxy)-propyl]-phenol 
• 88275-77-8 2-{(1R,2R,3R,5R)-5-Hydroxy-3-(tetrahydro-pyran-2-yloxy)-2-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl}-6-[3-(tetrahydro-pyran-2-yloxy)-propyl]-phenol 
• 93292-79-6 (1S,2R,3R,4R)-2-[2-Methoxy-3-(tetrahydro-pyran-2-yloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanol 
• 93381-42-1 (1R,2R,3R,4R)-2-[2-Methoxy-3-(tetrahydro-pyran-2-yloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanol 
• 88275-75-6 (2R,3R,4R)-2-{2-Methoxy-3-[3-(tetrahydro-pyran-2-yloxy)-propyl]-benzyl}-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanone 

Relevant articles and documents

Synthesis of 2-bromomethyl-2,3-dihydrobenzofurans from 2-allylphenols enabled by organocatalytic activation of: N -bromosuccinimide

2-Bromomethyl-2,3-dihydrobenzofurans are valuable and highly functionalized compounds that can be obtained by an intramolecular reaction between 2-allylphenols and a bromenium ion source (Br+). Due to the ineffectiveness of the safe and easy-to-handle brominating agent N-bromosuccinimide (NBS) to deliver the desired products, a catalytic process using a mixture of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and acetic acid was conceived. We hypothesized that this catalytic system delivers in situ acetyl hypobromite (AcOBr) as the active brominating agent, enabling the conversion of a range of 2-allylphenols with diverse electron densities to the products. The protocol was robust enough to permit the reaction to be scaled up to 10 mmols of starting material. Besides, the functional group interconversion with a 2-bromomethyl-2,3-dihydrobenzofuran derivative was successfully demonstrated. This journal is

THERAPEUTIC COMPOUNDS AND METHODS OF USE

The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Synthesis and biological evaluation of novel n-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl) formamide as a potent immunosuppressant agent

N-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl)-Formamide (1) was synthesized and its immunosuppressive activity was evaluated. The results showed it had highly immunosuppressive activity and can be studied as lead compound in the development of immunosuppressant agent.