172691-27-9

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 141277-18-1 (3S,4S,5R)-tert-butyl <6-(p-bromobenzyloxy)-4,5-epoxy-3-hydroxy>hexanoate 

Downstream Products

• 172691-23-5 (4S,5S)-5-[(S)-2-(4-Bromo-benzyloxy)-1-hydroxy-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-dihydro-furan-2-one 
• 172691-49-5 Benzoic acid (R)-2-(4-bromo-benzyloxy)-1-[(2S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-5-oxo-tetrahydro-furan-2-yl]-ethyl ester 
• 172293-72-0 (4S,5R,1'S)-5-<2'-<(4-Bromobenzyl)oxy>-1'-hydroxyethyl>-4-hydroxy-2-oxo-1-oxacyclopentane 

Relevant academic research and scientific papers

Synthesis of 2'-deoxynucleosides substituted in C-5'

Stereocontrolled lactonisation of γ,δ-epoxy β-hydroxyesters provides, after reduction, 2-deoxysugars in pyrano or furano form. After appropriate protection of the hydroxyl functions, these sugars can be converted to various 2'-deoxynucleosides with different configuration of the sugar moiety and an extra functionalisation at C-5.