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Urea, N-[4-[bis(2-chloroethyl)amino]phenyl]-N'-(4-hydroxyphenyl)-, also known as mechlorethamine, is an alkylating agent with the chemical formula C10H16Cl2N2O. It is a nitrogen mustard derivative used as an antineoplastic agent in chemotherapy, specifically for the treatment of various types of cancer, including Hodgkin's lymphoma and mycosis fungoides. Mechlorethamine works by cross-linking DNA strands, preventing cell division and ultimately leading to cell death. Due to its cytotoxic nature, it is crucial to handle this chemical with extreme caution and in accordance with proper safety protocols.

17273-08-4

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17273-08-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 17273-08-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,2,7 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 17273-08:
(7*1)+(6*7)+(5*2)+(4*7)+(3*3)+(2*0)+(1*8)=104
104 % 10 = 4
So 17273-08-4 is a valid CAS Registry Number.

17273-08-4Downstream Products

17273-08-4Relevant academic research and scientific papers

New prodrugs derived from 6-aminodopamine and 4-aminophenol as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT)

Knaggs, Sarah,Malkin, Hugh,Osborn, Helen M.I.,Williams, Nana Aba O.,Yaqoob, Parveen

, p. 4002 - 4010 (2005)

Two novel tyrosinase mediated drug delivery pathways have been investigated for the selective delivery of cytotoxic units to melanocytes from urea and thiourea prodrugs. The synthesis of these prodrugs is reported, as well as oximetry data that illustrate that the targets are substrates for tyrosinase. The stability of each of the prodrugs in (i) phosphate buffer and (ii) bovine serum is discussed, and the urea prodrugs are identified as lead candidates for further studies. Finally, HPLC studies and preliminary cytotoxicity studies in a melanotic and an amelanotic cell line, that illustrate the feasibility of the approach, are presented. The Royal Society of Chemistry 2005.

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