172732-63-7

Upstream product

• 172732-90-0 ((1-((1,1'-biphenyl)-3-ylmethyl)-2-methyl-1H-indol-4-yl)oxy)acetic acid methyl ester 
• 172732-89-7 1-((1,1'-biphenyl)-3-ylmethyl)-2-methyl-4-hydroxy-1H-indole 
• 17897-50-6 4-methoxy-2-methylindole 
• 172732-91-1 ((3-(2-amino-1,2-dioxoethyl)-1-((1,1'-biphenyl)-3-ylmethyl)-2-methyl-1H-indol-4-yl)oxy)acetic acid methyl ester 
• 1027890-74-9 (1-Biphenyl-3-ylmethyl-3-chlorooxalyl-2-methyl-1H-indol-4-yloxy)-acetic acid methyl ester 
• 172732-88-6 1-((1,1'-biphenyl)-3-ylmethyl)-2-methyl-4-methoxy-1H-indole 

Relevant academic research and scientific papers

Method for treating sepsis

A novel method of treating and/or preventing sepsis.

Method for the treatment of renal dysfunction with spla2 inhibitors

A method is disclosed for the treatment of of the symptoms associated with renal dysfunction by administering to an animal in need thereof a therapeutically effective amount of a sPLA2 inhibitor, such as a 1H-indole-3-glyoxylamide.

METHOD FOR TRATMENT OF NON-RHEUMATOID ARTHRITIS

A method is disclosed for the treatment of non-rheumatoid arthritis by administering to a mammal in need thereof a therapeutically effective amount of an sPLA 2 inhibitor.

Process for preparing toluenesulfinates

A process for preparing novel compounds useful in the preparation of 1H-indole-3-glyoxamides.

Method for the treatment of cystic fibrosis

A method is disclosed for the treatment of cystic fibrosis by administering to a human in need thereof a therapeutically effective amount of an sPLA2inhibitor, such as a 1H-indole-3-glyoxylamide.

SPLA2 inhibitor compounds for treatment of disease

The present invention is directed to compounds for treating inflammatory bowel disease. More specifically, the present invention is directed to 1H-indole-3-glyoxyamide compounds a sPLA2inhibitors for treating inflammatory bowel disease.

Process for preparing 4-substituted-1H-indole-3-glyoxamides

A process for preparing 1H-indole-3-glyoxamides useful for inhibiting SPLA2and novel intermediates useful in the preparation of such compounds.

Treatment for alzheimer's disease

This invention is a method of treating a mammal, including a human, susceptible to having Alzheimer's disease, to prevent or delay the onset of Alzheimer's disease; said method comprising administering to said mammal a prophylactically effective amount of

Morpholino-N-ethyl ester prodrugs of indole sPLA2 inhibitors

The compound, ((3(2-amino-1,2-dioxoethyl)-1-((1,1′-biphenyl)-3-ylmethyl)-2-methyl-1H-indol-4-yl)oxy)acetic acid morpholino-ethyl ester, is disclosed together with its use as a highly bioavailable indole compound for inhibiting sPLA2mediated release of fatty acids for treatment of conditions such as septic shock.

N,N-diethylglycolamido ester prodrugs of indole sPLA2 inhibitors

The compound, ((3-(2-amino-1,2-dioxoethyl)-1-((1,1′-biphenyl-3-ylmethyl)-2-methyl-1H-indol-4-yl)oxy)acetic acid N,N-diethylglycolamido ester, is disclosed together with its use as a highly bioavailable indole compound for inhibiting sPLA2mediated release of fatty acids for treatment of conditions such as septic shock.