172745-74-3Relevant articles and documents
Linear Natriuretic Peptide Constructs
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Page/Page column 32, (2008/06/13)
Linear constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group covalently bound to a reactive group of at least one of the amino acid residues or surrogates, pharmaceutical compositions including such linear constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.
Note on the Preparation of N-substituted Aminoglyceraldehydes
Angrick, Michael
, p. 645 - 650 (2007/10/02)
O-Benzyl-N-(benzyloxycarbonyl)-DL-serine methyl ester (1a) and peptides 1b-d with C-terminal O-benzylserine ester have been reduced with diisobutylaluminium hydride to yield the N-substituted aminoglyceraldehydes 2a-d.Using lithium tetrahydridoaluminate as the reducing agent the corresponding alcohols 3a-d have been obtained. - (Keywords: Maillard reaction; N-Substituted aminoglyceraldehydes)