172745-75-4

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 93-91-4 1-phenylbutan-1,3-dione 

Downstream Products

• 836595-83-6 10-hydroxy-10-methyl-8-oxo-6-phenylspiro[4,5]dec-6-en-7-carboxylic acid ethyl ester 
• 72157-59-6 1-methyl-4-phenyl-2,3-diazaspiro<4.4>nona-1,3-diene 

Relevant academic research and scientific papers

Synthesis of spiro[5.4]decenones and their transformation into bicyclo[4.4]deca-1,4-dien-3-ones by domino "elimination-double-Wagner- Meerwein-rearrangement" reactions

The [3+3] cyclization of 1,3-bis-silyl enol ethers with 1,1-diacylcyclopentanes allows a convenient synthesis of spiro[5.4]decenones. Treatment of these compounds with trifluoroacetic acid (TFA) afforded a great variety of bicyclo[4.4.0]deca-1,4-dien-3-on

Diastereo- and regioselective synthesis of diquinanes and related systems from tricyclo[3.3.0.02,4]octanes by chemical electron transfer (CET)

A new synthetic methodology for diquinanes by one-electron oxidation of tricyclo[3.3.0.02,4]octanes and subsequent stereocontrolled rearrangement is provided. The latter compounds are conveniently accessible through acid-catalyzed isopyrazole cycloaddition, followed by hydrogenation and photoextrusion of molecular nitrogen. The oxidative rearrangement of the tricyclooctanes proceeds catalytically and cleanly to afford regio- and diastereoselectively the corresponding diquinanes.