172748-80-0

Basic information

• Product Name: (S)-(-)-1-(3'-chlorophenyl)propan-1-o
• Synonyms: (S)-(-)-1-(3'-chlorophenyl)propan-1-o;(S)-1-(3-chlorophenyl)propanol
• CAS NO: 172748-80-0
• Molecular Formula: C₉H₁₁ClO
• Molecular Weight: 170.63604
• Mol File: 172748-80-0.mol
• Article Data: 69

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-(-)-1-(3'-chlorophenyl)propan-1-o(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-1-(3'-chlorophenyl)propan-1-o(172748-80-0)
• EPA Substance Registry System: (S)-(-)-1-(3'-chlorophenyl)propan-1-o(172748-80-0)

Safety Data

• Hazardous Substances Data: 172748-80-0(Hazardous Substances Data)

Usage

General Description

(S)-(-)-1-(3'-chlorophenyl)propan-1-o is a chemical compound with the molecular formula C9H11Cl. It is an enantiomer of the compound 1-(3'-chlorophenyl)propan-1-o, with a specific stereochemistry that gives it unique properties. (S)-(-)-1-(3'-chlorophenyl)propan-1-o is commonly used as a chiral building block in the synthesis of pharmaceuticals and agrochemicals. It has been identified as a key intermediate in the production of various drugs and can be used in the manufacture of chiral drug molecules. The compound has potential applications in organic synthesis and medicinal chemistry due to its stereochemical properties. Additionally, it has been studied for its pharmacological activities, including its potential as an anti-inflammatory agent and its effect on the central nervous system.

Upstream product

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Relevant articles and documents

Deciphering the mechanism behind efficient enantioselective ethylation with thiazolidine-based amino alcohols

Taking advantage of the opposite chirality of two privileged starting materials, l-cysteine and d-penicillamine, a wide range of thiazolidine-based amino alcohols was synthesized. l-Cysteine derivatives were more efficient chiral inductors than the d-peni

Chiral P,N-ligands for the highly enantioselective addition of diethylzinc to aromatic aldehydes

A new sterically hindered chiral P,N-ligand was synthesized and successfully applied to copper catalyzed asymmetric addition of diethylzinc to aromatic aldehydes. Various aromatic aldehydes can react smoothly to give the corresponding addition products with good to excellent enantioselectivities, which provides a readily accessible method for the preparation of chiral secondary alcohols.

Chiral thiazolidines in the enantioselective ethylation of aldehydes: An experimental and computational study

A library of new chiral thiazolidines was prepared starting from L-cysteine and D-penicillamine in a simple, one-step procedure. 2-Arylthiazolidines were obtained, as diastereoisomeric mixtures, with good yields and in short reaction times, through a new and greener procedure, using microwave irradiation. Their use as chiral ligands in the enantioselective ethylation of aromatic aldehydes was studied and optimized, originating good to excellent conversions and ee up to 94% in 6 h. A series of heteroaromatic and aliphatic substrates were also enantioselectively ethylated with success, with ee up to 77%. The distinct opposite chirality in L-cysteine and D-penicillamine makes the use of these ligands an interesting approach for obtaining both the (S) and (R) enantiomers of the chiral alcohols, compounds with potential applications in the area of fine chemistry. NMR studies were carried out using a diastereoisomeric mixture of thiazolidines, allowing the identification of the most stable structure. Computational studies confirmed this result and also gave important insight into the species involved in the catalytic cycle of the enantioselective alkylation.