172798-41-3Relevant academic research and scientific papers
Studies on the preparation of bioactive lignans by oxidative coupling reaction. VI. Oxidation of methyl (E)-3-(4,5-dihydroxy-2-methoxyphenyl)-2- butenoate and lipid peroxidation-inhibitory effects of the produced caffeoquinone
Maeda,Masuda,Tokoroyama
, p. 1588 - 1591 (1995)
Oxidation of hydroxy-α-methylcinnamate 5 derived from 4-methylesculetin afforded the α-methylcaffeoquinone derivative 7 without formation of the oxidative coupling product. The reaction of the α-methylferulate derivative 13 afforded a complex mixture of products. Thus, the hydroxy-α- methylcinnamates seem not to be suitable substrates for oxidative coupling. Compound 7 was tested for inhibitory effect on lipid peroxidation. It showed more potent activity than idebenone in rat brain homogenate, and was much more potent than (±)-α-tocopherol in rat liver microsomes.
