Chemical and Pharmaceutical Bulletin p. 1588 - 1591 (1995)
Update date:2022-08-02
Topics:
Maeda
Masuda
Tokoroyama
Oxidation of hydroxy-α-methylcinnamate 5 derived from 4-methylesculetin afforded the α-methylcaffeoquinone derivative 7 without formation of the oxidative coupling product. The reaction of the α-methylferulate derivative 13 afforded a complex mixture of products. Thus, the hydroxy-α- methylcinnamates seem not to be suitable substrates for oxidative coupling. Compound 7 was tested for inhibitory effect on lipid peroxidation. It showed more potent activity than idebenone in rat brain homogenate, and was much more potent than (±)-α-tocopherol in rat liver microsomes.
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(1995)Doi:10.1016/0022-328X(95)05542-W
(1995)
