1728-24-1Relevant articles and documents
CERTAIN FUSED PYRROLECARBOXAMIDES A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS
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, (2008/06/13)
Disclosed are compounds of formula I: STR1 wherein R 8 and R. sub.9 independently represent hydrogen or organic substituents; W represents optionally substituted thiazolyl or quinoxalinyl; X is hydrogen, hydroxy or lower alkyl; andT is hydrogen, halogen, hydroxy, nitro, amino or alkyl,which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptor. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.
CERTAIN PYRROLO PYRIDINE-3-CARBOXAMIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS
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, (2008/06/13)
The present invention encompasses structures of the formula: STR1 or the pharmaceutically acceptable non-toxic salts thereof wherein: STR2 wherein: W represents substituted or unsubstituted phenyl;X is hydrogen, hydroxy or lower alkyl; T is hydrogen, halogen, hydroxy, nitro, amino or alkyl; R. sub.3 is hydrogen or an organic group;R 4 is hydrogen or substituted or unsubstituted organic substituent;R 5 and R 6 represent organic, and inorganic substituents; andn is 1, 2, 3, or 4, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.
Synthetic studies on the 1-hydroxy nortropane system: An approach to Calystegines.
Ducrot, P.-H.,Beauhaire, J.,Lallemand, J. Y.
, p. 3883 - 3886 (2007/10/02)
A general synthetic strategy for 1-hydroxy nortropane skeleton, the common feature of calystegines is described.