17283-02-2

Basic information

• Product Name: 2,4-diphenylquinoline-3-carbonitrile
• Synonyms: 2,4-diphenylquinoline-3-carbonitrile
• CAS NO: 17283-02-2
• Molecular Weight: 306.367
• Mol File: 17283-02-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4-diphenylquinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-diphenylquinoline-3-carbonitrile(17283-02-2)
• EPA Substance Registry System: 2,4-diphenylquinoline-3-carbonitrile(17283-02-2)

Safety Data

• Hazardous Substances Data: 17283-02-2(Hazardous Substances Data)

Upstream product

• 614-16-4 Benzoylacetonitrile 
• 118-48-9 isatoic anhydride 
• 56289-93-1 4-chloro-2-phenylquinoline-3-carbonitrile 
• 98-80-6 phenylboronic acid 
• 141259-11-2 4-oxo-2-phenyl-1,4-dihydroquinoline-3-carbonitrile 

Relevant articles and documents

DABCO-mediated decarboxylative cyclization of isatoic anhydride with aroyl/heteroaroyl/alkoylacetonitriles under microwave conditions: Strategy for the synthesis of substituted 4-quinolones

An efficient, 1,4-diazabicyclo[2.2.2]octane(DABCO)-mediated decarboxylative cyclization of isatoic anhydrides with active methylene groups namely aroyl/heteroaroyl/alkoylacetonitriles under microwave condition was developed for the synthesis of substituted 4-quinolones. This method utilizes commercially available substrates, occurs under mild conditions, short reaction time, good to excellent yields, easy scale-up, and is compatible with a wide substrate scope. 4-Quinolones (3) obtained by this DABCO-mediated approach were further explored in order to evaluate their synthetic applicability. Initially, 4-quinolone derivatives were efficiently transformed into corresponding 4-Chloro-2-phenyl-quinoline-3-carbonitriles. Further, 2,4-Diphenyl-quinoline-3-carbonitriles were prepared by palladium catalyzed Suzuki-Miyaura cross-coupling of 4-Chloro-2-phenyl-quinoline-3-carbonitrile with aryl boronic acids.