56289-93-1

Basic information

• Product Name: 4-chloro-2-phenylquinoline-3-carbonitrile
• Synonyms: 4-chloro-2-phenylquinoline-3-carbonitrile
• CAS NO: 56289-93-1
• Molecular Weight: 264.714
• Mol File: 56289-93-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-2-phenylquinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-phenylquinoline-3-carbonitrile(56289-93-1)
• EPA Substance Registry System: 4-chloro-2-phenylquinoline-3-carbonitrile(56289-93-1)

Safety Data

• Hazardous Substances Data: 56289-93-1(Hazardous Substances Data)

Upstream product

• 614-16-4 Benzoylacetonitrile 
• 118-48-9 isatoic anhydride 
• 141259-11-2 4-oxo-2-phenyl-1,4-dihydroquinoline-3-carbonitrile 

Downstream Products

• 17283-02-2 2,4-diphenylquinoline-3-carbonitrile 

Relevant articles and documents

DABCO-mediated decarboxylative cyclization of isatoic anhydride with aroyl/heteroaroyl/alkoylacetonitriles under microwave conditions: Strategy for the synthesis of substituted 4-quinolones

An efficient, 1,4-diazabicyclo[2.2.2]octane(DABCO)-mediated decarboxylative cyclization of isatoic anhydrides with active methylene groups namely aroyl/heteroaroyl/alkoylacetonitriles under microwave condition was developed for the synthesis of substituted 4-quinolones. This method utilizes commercially available substrates, occurs under mild conditions, short reaction time, good to excellent yields, easy scale-up, and is compatible with a wide substrate scope. 4-Quinolones (3) obtained by this DABCO-mediated approach were further explored in order to evaluate their synthetic applicability. Initially, 4-quinolone derivatives were efficiently transformed into corresponding 4-Chloro-2-phenyl-quinoline-3-carbonitriles. Further, 2,4-Diphenyl-quinoline-3-carbonitriles were prepared by palladium catalyzed Suzuki-Miyaura cross-coupling of 4-Chloro-2-phenyl-quinoline-3-carbonitrile with aryl boronic acids.