172846-35-4Relevant academic research and scientific papers
Synthesis of 17H-tetrabenzofluorene derivatives as chiral selectors for enantiomeric separation by HPLC on porous graphitised carbon
Dutton, Jonathan K.,Knox, John H.,Radisson, Xavier,Ritchie, Harold J.,Ramage, Robert
, p. 2581 - 2588 (2007/10/02)
The synthesis of the amides 2 which are designed to be selectors containing the chiral N-(3,5-dinitrobenzoyl)-α-phenylglycine covalently linked to tetrabenzofluorene is described.These amides are strongly adsorbed onto porous graphitised carbon, which affords chiral stationary phases that are able to resolve both racemic aromatic alcohols 3 and the methyl esters of Fmoc amino acids 4 on microgram quantities using high-pressure liquid chromatography.Two methods of preparation of these chiral phases from 2 and porous graphitised carbon are described and the stability of these phases to the chromatographic conditions and to water have also been investigated.
