172876-72-1

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 24331-75-7 (2-methyl-benzylidene)-malonic acid diethyl ester 
• 95-46-5 2-methylphenyl bromide 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 529-20-4 2-methylphenyl aldehyde 
• 105-53-3 diethyl malonate 

Downstream Products

• 172876-75-4 β-(2,2'-Dimethylbenzhydryl)glutaronitrile 
• 172876-74-3 2-(2,2'-Dimethylbenzhydryl)propane-1,3-diol bismethanesulfonate 
• 172876-76-5 β-(2,2'-Dimethylbenzhydryl)glutaric acid 
• 500794-59-2 (2,2'-dimethyl-benzhydryl)-malonic acid 
• 172876-73-2 2-(2,2'-Dimethylbenzhydryl)propane-1,3-diol 

Relevant academic research and scientific papers

A facile one-step synthesis of ethyl 2-(1,1-dialkyl and arylmethyl) malonates

Diethyl ethoxymethylenemalonate (EMME) is unexpectedly converted into diethyl 2-(1,1-dialkyl and diarylmethyl) malonate derivatives by a classical Grignard reaction. Addition of organocuprates to EMME gave diethyl 2-(1- ethoxyalkyl) malonate derivatives.

Synthesis of Helical Molecules Based on 5,6,6a,7,8,12b-Hexahydrobenzophenanthrene-5,8-dione

Synthetic routes based on Newman'synthesis of a number of polycyclic aromatic hydrocarbons were modified and developed to give a convenient preparation (Scheme 1) of 11 helical molecules formally based on hexalindione (1).In contrast to Newman's work, we