17288-55-0

Basic information

• Product Name: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBALDEHYDE
• Synonyms: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBALDEHYDE;5-methoxy-1H-Pyrrolo[3,2-b]pyridine-3-carboxaldehyde
• CAS NO: 17288-55-0
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17
• Mol File: 17288-55-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 363.3°C at 760 mmHg
• Flash Point: 173.5°C
• Appearance: /
• Density: 1.347g/cm³
• Vapor Pressure: 1.82E-05mmHg at 25°C
• Refractive Index: 1.691
• CAS DataBase Reference: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBALDEHYDE(17288-55-0)
• EPA Substance Registry System: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBALDEHYDE(17288-55-0)

Safety Data

• Hazardous Substances Data: 17288-55-0(Hazardous Substances Data)

Usage

General Description

5-Methoxy-1H-pyrrolo[3,2-b]pyridine-3-carbaldehyde is a chemical compound with a complex molecular structure. It contains a pyrrolopyridine core with a methoxy substituent at position 5 and an aldehyde functional group at position 3. 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBALDEHYDE has potential applications in medicinal chemistry and drug discovery due to its unique structure and potential biological activities. It may be used as a building block in the synthesis of various pharmaceuticals and organic molecules. Its specific properties and potential uses can be further studied and explored in research and development efforts.

InChI:InChI=1/C9H8N2O2/c1-13-8-3-2-7-9(11-8)6(5-12)4-10-7/h2-5,10H,1H3

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 17288-40-3 5-methoxy-4-aza-1H-indole 
• 5446-92-4 2-methoxy-5-nitropyridine 
• 5467-69-6 6-methoxy-3-nitro-2-picoline 
• 111795-99-4 2-(6-methoxy-3-nitropyridin-2-yl)acetonitrile 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 1027068-77-4 5-oxo-4,5-dihydro-1H-pyrrolo<3,2-b>pyridine-3-carbaldehyde 

Relevant articles and documents

3-SUBSTITUTED-1H-INDOLE, 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES

The invention relates to 3-substituted-1H-indole, 3-substituted-1H-pyrrolo[2,3-b]pyridine, and 3-substituted-1H-pyrrolo[3,2-b]pyridine compounds of the Formula (I): or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.

PPAR ACTIVE COMPOUNDS

Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

The serotonin 5-HT4 receptor. 2. Structure-activity studies of the indole carbazimidamide class of agonists.

A number of substituted indole carbazimidamides were prepared and evaluated as 5-HT4 receptor agonists by using the isolated field-stimulated guinea pig ileum preparation. Their selectivity for the 5-HT4 receptor was established by examining their affinity for other 5-HT receptors using radioligand-binding techniques. Several selective and highly potent full as well as partial agonists emerged from this study. For example, 1b,d were found to be the most potent, full 5-HT4 receptor agonist described so far (EC50 = 0.5 and 0.8 nM, respectively), being 6 and 4 times more potent than serotonin itself. On the other hand, 5b and 1h appeared as partial 5-HT4 receptor agonists in the nonstimulated guinea pig ileum preparation with potencies, evaluated against serotonin action, respectively similar (5b, Ki = 12 nM) to and 300-fold higher (1h, Ki = 0.04 nM) than serotonin.