172881-12-8

Basic information

• Product Name: Propenal O-(4-chloro-benzyl)-oxime
• CAS NO: 172881-12-8
• Molecular Weight: 195.648
• Mol File: 172881-12-8.mol

Chemical Properties

• CAS DataBase Reference: Propenal O-(4-chloro-benzyl)-oxime(CAS DataBase Reference)
• NIST Chemistry Reference: Propenal O-(4-chloro-benzyl)-oxime(172881-12-8)
• EPA Substance Registry System: Propenal O-(4-chloro-benzyl)-oxime(172881-12-8)

Safety Data

• Hazardous Substances Data: 172881-12-8(Hazardous Substances Data)

Upstream product

• 38936-60-6 O-(4-chlorobenzyl)hydroxylamine hydrochloride 
• 107-02-8 acrolein 

Downstream Products

• 172881-26-4 Oxirane-2-carbaldehyde O-(4-chloro-benzyl)-oxime 

Relevant articles and documents

Synthesis and β-adrenergic properties of (E)-N-[3-(alkylamino)-2-hydroxypropylidene](methyloxy)amines substituted with an aromatic group on their [(methyloxy)imino]methyl moiety (MOIMM): An investigation into the biopharmacological effects of an aryl substitution in the class of MOIM β-blocking drugs

N-Isopropyl-(5a-g) and N-t-butyl-substituted (6a-g) (E)-N-[3-(amino)-2-hydroxypropylidene](arylmethyloxy)amines, which present an aromatic ring (Ar) linked to the CH2 carbon of the [(methyloxy)imino]methyl moiety (MOIMM), were synthesized with the aim of comparing their β-adrenergic properties with those of the previously studied completely aliphatic analogs 1,2 and 3,4. Compounds 5 and 6 were tested for their affinity towards β1- and β2-adrenoceptors by radioligand binding experiments; the compounds with the highest affinity were also assayed for their β1- and β2-adrenergic activity by functional tests on isolated preparations. The biopharmacological results show that, for the MOIM derivatives studied (1-6), the presence of an Ar substituent linked to the MOIM, as in 5 and 6, does not have any appreciable effect on the β1-adrenergic properties in terms of affinity and activity; this type of substituent, on the contrary, appears to be capable of improving the β2-adrenergic properties, as far as the receptor affinity is concerned. These results are discussed on the basis of a comparison of the conformational and electronic characteristics.

Synthesis and β-adrenergic properties of (Z)-N-[3-(alkylamino)-2-hydroxypropylidene](aryl-methyloxy)amines: Effects of the configuration around the methyloxyiminomethyl (MOIM) double bond on the biopharmacological properties of MOIM-type β-blocking agents

The N-isopropyl- (3a-g) and N-tert-butyl-substituted (4a-g) (Z)-N-(3-(amino)-2-hydroxypropylidene)(arylmethyloxy)amines were synthesized in order to compare their β1- and β2-adrenergic properties with those of their previously studie