17289-25-7

Basic information

• Product Name: (1-METHYL-1H-IMIDAZOL-4-YL)METHANOL
• Synonyms: (1-METHYL-1H-IMIDAZOL-4-YL)METHANOL;1-Methyl-4-imidazolemethanol;4-(Hydroxymethyl)-1-methylimidazole;(1-Methyl-1H-imidazol-4-yl)methanol97%
• CAS NO: 17289-25-7
• Molecular Formula: C₅H₈N₂O
• Molecular Weight: 112.13
• Mol File: 17289-25-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 59.5-63.5
• Boiling Point: 324.9 °C at 760 mmHg
• Flash Point: 150.3 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 9.76E-05mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: 2-8°C
• PKA: 13.61±0.10(Predicted)
• CAS DataBase Reference: (1-METHYL-1H-IMIDAZOL-4-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (1-METHYL-1H-IMIDAZOL-4-YL)METHANOL(17289-25-7)
• EPA Substance Registry System: (1-METHYL-1H-IMIDAZOL-4-YL)METHANOL(17289-25-7)

Safety Data

• Hazard Codes: Harmful:
• Hazardous Substances Data: 17289-25-7(Hazardous Substances Data)

Usage

General Description

(1-Methyl-1H-imidazol-4-yl)methanol, also known as MIM, is a chemical compound with the molecular formula C5H8N2O. It is a colorless liquid that is commonly used in organic synthesis and as a reagent in various chemical reactions. MIM is considered to be a versatile building block for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is known for its ability to participate in various types of chemical transformations, such as alkylation, nucleophilic addition, and reduction reactions. Additionally, (1-Methyl-1H-imidazol-4-yl)methanol has been studied for its potential biological and pharmacological activities, making it a compound of interest in medicinal and pharmaceutical research.

InChI:InChI=1/C5H8N2O/c1-7-2-5(3-8)6-4-7/h2,4,8H,3H2,1H3

Upstream product

• 822-55-9 (1H-imidazol-4-yl)methanol 
• 127056-46-6 4-((tert-butyldimethylsilyloxy)methyl)-1-methyl-1H-imidazole 
• 41716-18-1 1-methylimidazole-4-carboxylic acid 

Downstream Products

• 657398-99-7 C₄₄H₃₆N₆O 
• 656240-13-0 7-methyl-2-(6-methyl-pyridin-2-yl)-3-[2-(4-((1-methyl-imidazol-4-yl)methyloxy)phenyl)-pyridin-4-yl]-imidazo[1,2-a]pyridine 
• 657399-49-0 4-(2-tert-butyl-5-{6-methyl}-pyridin-2-yl-1H-imidazol-4-yl)-2-[4-(1-methyl-1H-imidazol-4-ylmethoxy)-phenyl]-pyridine 
• 112258-59-0 4-chloromethyl-1-methyl-1H-imidazole 
• 657399-52-5 4-(2-tert-butyl-5-pyridin-2-yl-1H-imidazol-4-yl)-2-[4-(1-methyl-1H-imidazol-4-ylmethoxy)-phenyl]-pyridine 
• 17289-30-4 4-(chloromethyl)-1-methyl-1H-imidazole hydrochloride 
• 17289-26-8 1-methyl-1H-imidazole-4-carbaldehyde 

Relevant articles and documents

BIARYL PYRAZOLES AS NRF2 REGULATORS

The present invention relates to biaryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.

COMPOUNDS

The invention relates to novel aminothiazole derivatives which are inhibitors of the transforming growth factor, ("TGF")-? signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ("ALK")-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

PYRAZOLE INHIBITORS OF THE TRANSFORMING GROWTH FACTOR

The invention relates to novel pyrazole derivatives of formula (I), which are inhibitors of the transforming growth factor, ("TGF")-? signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ("ALK")-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.