17289-25-7

Usage

Uses

Used in Organic Synthesis:
(1-METHYL-1H-IMIDAZOL-4-YL)METHANOL is used as a versatile building block for the synthesis of a wide range of compounds, including pharmaceuticals, agrochemicals, and other fine chemicals. Its ability to participate in various chemical transformations, such as alkylation, nucleophilic addition, and reduction reactions, makes it a valuable component in the development of new and innovative chemical products.
Used in Chemical Reactions:
(1-METHYL-1H-IMIDAZOL-4-YL)METHANOL is used as a reagent in various chemical reactions, facilitating the formation of desired products and improving the efficiency of the reaction process. Its compatibility with a range of reaction types and its ability to act as a nucleophile or an electrophile contribute to its utility in the synthesis of complex organic molecules.
Used in Medicinal and Pharmaceutical Research:
(1-METHYL-1H-IMIDAZOL-4-YL)METHANOL is used as a compound of interest in medicinal and pharmaceutical research due to its potential biological and pharmacological activities. Its unique chemical properties and reactivity make it a promising candidate for the development of new drugs and therapeutic agents, with applications in various medical fields.
Used in Chemical Industry:
(1-METHYL-1H-IMIDAZOL-4-YL)METHANOL is used as a key intermediate in the production of various chemical products, such as dyes, pigments, and polymers. Its ability to form stable complexes with other molecules and its compatibility with a wide range of chemical processes make it an essential component in the chemical industry.

InChI:InChI=1/C5H8N2O/c1-7-2-5(3-8)6-4-7/h2,4,8H,3H2,1H3

Upstream product

• 822-55-9 (1H-imidazol-4-yl)methanol 
• 41716-18-1 1-methylimidazole-4-carboxylic acid 
• 127056-46-6 4-((tert-butyldimethylsilyloxy)methyl)-1-methyl-1H-imidazole 

Downstream Products

• 17289-26-8 1-methyl-1H-imidazole-4-carbaldehyde 
• 17289-30-4 4-(chloromethyl)-1-methyl-1H-imidazole hydrochloride 
• 657399-52-5 4-(2-tert-butyl-5-pyridin-2-yl-1H-imidazol-4-yl)-2-[4-(1-methyl-1H-imidazol-4-ylmethoxy)-phenyl]-pyridine 
• 657398-99-7 C₄₄H₃₆N₆O 
• 656240-13-0 7-methyl-2-(6-methyl-pyridin-2-yl)-3-[2-(4-((1-methyl-imidazol-4-yl)methyloxy)phenyl)-pyridin-4-yl]-imidazo[1,2-a]pyridine 
• 657399-49-0 4-(2-tert-butyl-5-{6-methyl}-pyridin-2-yl-1H-imidazol-4-yl)-2-[4-(1-methyl-1H-imidazol-4-ylmethoxy)-phenyl]-pyridine 
• 112258-59-0 4-chloromethyl-1-methyl-1H-imidazole 

Relevant academic research and scientific papers

BIARYL PYRAZOLES AS NRF2 REGULATORS

The present invention relates to biaryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.

New asymmetric synthesis of protein farnesyltransferase inhibitors via palladium-catalyzed cross-coupling reactions of 2-iodo-imidazoles

Palladium catalyzed cross-coupling reactions of 2-iodoimidazole have been studied to synthesize imidazole-containing protein farnesyltransferase inhibitors. The Suzuki coupling reaction proved to be very efficient to introduce functionalized alkyl chains at the 2-position of the imidazole ring and a new synthesis of the required alkenylboronates was realised by a reaction of cross metathesis. Asymmetric synthesis of allyl succinic derivatives allowed us to synthesize chiral protein farnesyltransferase inhibitors through Suzuki coupling and to determine the influence of the stereochemistry of our inhibitors on the enzymatic activity.

2-PHENYLPYRIDIN-4-YL DERIVATIVES AS ALK5 INHIBITORS

This invention relates to novel 2-phenylpyridin-4-yl heterocyclyl derivatives which are inhibitors of the transforming growth factor, ("TGF")-? signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ("ALK")-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

PYRAZOLE INHIBITORS OF THE TRANSFORMING GROWTH FACTOR

The invention relates to novel pyrazole derivatives of formula (I), which are inhibitors of the transforming growth factor, ("TGF")-? signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ("ALK")-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

Substituted triazolo-pyridazine derivatives as ligands for GABA receptors

Substituted triazolo-pyridazine derivative compounds represented by wherein the variables are disclosed herein are selective ligands for GABA-A receptors, particularly for the α2 and/or α3 subunits.