172896-68-3Relevant academic research and scientific papers
An efficient synthesis of a class of novel N-alkyl-N-aryl-4-hydroxy-1-methyl-2-oxo-1,2-dihydro-3- quinolinecarbothioamides
Spears, Glen W.,Tsuji, Kiyoshi,Tojo, Takashi,Nishimura, Hiroaki,Ogino, Takashi
, p. 799 - 804 (2007/10/03)
The novel title compounds have been prepared in high yield by an optimized amide coupling followed by a Dieckmann cyclization. Additionally, this new route is amenable to preparative scale synthesis.
Quinoline-3-carbothioamides and related compounds as novel immunomodulating agents
Tojo, Takashi,Spears, Glen W,Tsuji, Kiyoshi,Nishimura, Hiroaki,Ogino, Takashi,Seki, Nobuo,Sugiyama, Aiko,Matsuo, Masaaki
, p. 2427 - 2430 (2007/10/03)
A series of quinoline-3-carbothioamides and their analogues was prepared via four synthetic routes and evaluated for their antinephritic and immunomodulating activities. The optimal compound 9g strongly inhibited the T-cell independent antibody production in mice immunized with TNP-LPS and was highly effective in two nephritis models, namely chronic graft-versus-host disease and autoimmune MRL/l mice.
