172900-84-4

Upstream product

• 18880-00-7 1-(bromomethyl)-4-(1,1-dimethylethyl)benzene 
• 172900-79-7 1-bromo-2(R)-isopropyl-3-(p-tert-butyl-phenyl)-propane 
• 172900-80-0 2(R)-isopropyl-3-(p-tert-butyl-phenyl)-propanol 
• 98-51-1 4-tert-butyltoluene 

Downstream Products

• 173007-38-0 C₃₁H₅₂N₂O₄ 
• 172900-95-7 N-tert-butoxycarbonyl-2-methylene-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(p-tert-butyl-phenyl)-octanoic acid (N-butyl) amide 

Relevant academic research and scientific papers

Design and synthesis of novel 2,7-dialkyl substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro potent peptidomimetic inhibitors of human renin

Novel low-molecular weight transition-state peptidomimetic renin inhibitors characterized by an all-carbon 8-phenyl substituted octanecarboxamide skeleton have been discovered based on a topographical design approach. The in vitro most potent inhibitors 21, 25 and 26 incorporating a strong H-bond acceptor group linked to the benzyl spacer of the (P3-P1)-unit had IC50s in the low nanomolar range against human renin.