172906-90-0 Usage
Uses
PB 28 is a selective σ2 receptor agonist. It is also an antitumor and cytotoxic agent.
Biological Activity
High affinity σ 2 receptor agonist (K i values are 0.8 and 15.2 nM for σ 2 and σ 1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC 50 values are 2.62 and 3.96 μ M respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.
Check Digit Verification of cas no
The CAS Registry Mumber 172906-90-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,9,0 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 172906-90:
(8*1)+(7*7)+(6*2)+(5*9)+(4*0)+(3*6)+(2*9)+(1*0)=150
150 % 10 = 0
So 172906-90-0 is a valid CAS Registry Number.
InChI:InChI=1/C24H38N2O.2ClH/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21;;/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3;2*1H
172906-90-0Relevant articles and documents
1-Substituted-4-[3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1- yl)propyl]piperazines: Influence of the N-1 piperazine substituent on 5- HT(1A) receptor affinity and selectivity versus D2 and α1 receptors. Part 6
Perrone, Roberto,Berardi, Francesco,Colabufo, Nicola A.,Leopoldo, Marcello,Tortorella, Vincenzo
, p. 873 - 881 (2000)
In the present paper, we report the synthesis and the binding profiles on 5-HT(1A), D2, and α1 receptors of 1-substituted-4-[3-(5- or 7-methoxy- 1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine derivatives 19-32 and some related h
