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172906-90-0

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172906-90-0 Usage

Uses

PB 28 is a selective σ2 receptor agonist. It is also an antitumor and cytotoxic agent.

Biological Activity

High affinity σ 2 receptor agonist (K i values are 0.8 and 15.2 nM for σ 2 and σ 1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC 50 values are 2.62 and 3.96 μ M respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.

Check Digit Verification of cas no

The CAS Registry Mumber 172906-90-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,9,0 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 172906-90:
(8*1)+(7*7)+(6*2)+(5*9)+(4*0)+(3*6)+(2*9)+(1*0)=150
150 % 10 = 0
So 172906-90-0 is a valid CAS Registry Number.
InChI:InChI=1/C24H38N2O.2ClH/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21;;/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3;2*1H

172906-90-0 Well-known Company Product Price

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  • Sigma

  • (P9246)  PB28 dihydrochloride  ≥98% (HPLC), solid

  • 172906-90-0

  • P9246-5MG

  • 1,048.32CNY

  • Detail

172906-90-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name PB28 dihydrochloride

1.2 Other means of identification

Product number -
Other names 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine,dihydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:172906-90-0 SDS

172906-90-0Downstream Products

172906-90-0Relevant academic research and scientific papers

1-Substituted-4-[3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1- yl)propyl]piperazines: Influence of the N-1 piperazine substituent on 5- HT(1A) receptor affinity and selectivity versus D2 and α1 receptors. Part 6

Perrone, Roberto,Berardi, Francesco,Colabufo, Nicola A.,Leopoldo, Marcello,Tortorella, Vincenzo

, p. 873 - 881 (2000)

In the present paper, we report the synthesis and the binding profiles on 5-HT(1A), D2, and α1 receptors of 1-substituted-4-[3-(5- or 7-methoxy- 1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine derivatives 19-32 and some related h

New σ and 5-HT(1A) receptor ligands: ω-(tetralin-1-yl)-n-alkylamine derivatives

Berardi,Colabufo,Giudice,Perrone,Tortorella,Govoni,Lucchi

, p. 176 - 182 (1996)

Two series of compounds that are structurally related to benzomorphans, derived by structural modification of arylpiperazines with high 5-HT(1A) affinity and moderate σ affinity, were prepared in order to increase σ affinity and selectivity. All new compo

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