17291-90-6

Basic information

• Product Name: 2,6-Difluorophenethylamine97%
• Synonyms: 2,6-Difluorophenethylamine97%;2,6-DIFLUOROPHENETHYLAMINE 97%;BenzeneethanaMine, 2,6-difluoro-;2,6-Difluorophenethylamine
• CAS NO: 17291-90-6
• Molecular Formula: C₈H₉F₂N
• Molecular Weight: 157.1605664
• Mol File: 17291-90-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 193℃
• Flash Point: 83℃
• Appearance: /
• Density: 1.169
• PKA: 9.04±0.10(Predicted)
• CAS DataBase Reference: 2,6-Difluorophenethylamine97%(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluorophenethylamine97%(17291-90-6)
• EPA Substance Registry System: 2,6-Difluorophenethylamine97%(17291-90-6)

Safety Data

• Hazardous Substances Data: 17291-90-6(Hazardous Substances Data)

Usage

General Description

2,6-Difluorophenethylamine, with a purity level of 97%, is a type of fluorinated compound primarily used in the fields of pharmaceuticals, agrochemicals, and performance materials. As an intermediate, it plays a crucial role in complex chemical synthesis, contributing to the development of new and more effective drugs, pesticides, or specialized industrial materials. Being fluorinated enhances its potential for bioactivity and stability, thus opening more possibilities for product development. However, it should be handled with care due to its potentially hazardous properties. Safety measures are necessary to prevent risk of harm to individuals and the environment.

Upstream product

• 654-01-3 (2,6-difluorophenyl)acetonitrile 
• 20263-81-4 3,5-difluoro-β-nitrostyrene 

Downstream Products

• 149487-94-5 1-[2-(2,6-Difluoro-phenyl)-ethyl]-3-(5-methyl-pyridin-2-yl)-thiourea 
• 149488-22-2 N-(2-(2,6-difluorophenyl)ethyl)-N'-(2-pyrazinyl)-thiourea 
• 149488-13-1 1-(5-Bromo-pyridin-2-yl)-3-[2-(2,6-difluoro-phenyl)-ethyl]-thiourea 
• 149487-88-7 N-(thioimidazolyl)-2-(2,6-difluorophenyl)ethylamine 
• 149488-58-4 1-(4-Cyano-thiazol-2-yl)-3-[2-(2,6-difluoro-phenyl)-ethyl]-thiourea 
• 149487-86-5 1-[2-(2,6-Difluoro-phenyl)-ethyl]-3-(4-ethyl-thiazol-2-yl)-thiourea 

Relevant articles and documents

DOLASTATIN-10 DERIVATIVE, METHOD OF PRODUCING SAME AND ANTICANCER DRUG COMPOSITION CONTAINING SAME

The present invention provides a dolastatin-10 derivative having excellent anticancer activity, a method of producing the same and anticancer drug composition containing the same as an active ingredient.

Method for inhibition of HIV related viruses

Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.

Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs

A novel series of potent specific HIV-1 inhibitory compounds is described. The lead compound in the series, N-(2-phenethyl)-N'-(2-thiazolyl)thiourea (1), inhibits HIV-1 RT using rCdG as the template with an IC50 of 0.9 μM. In MT-4 cells, compound 1 inhibits HIV-1 with an ED50 of 1.3 μM. The 50% cytotoxic dose in cell culture is >380 μM. The chemical structure-activity relationship (SAR) was developed by notionally dividing the lead compound in four quadrants. The SAR strategy had two phases. The first phase involved optimization of antiviral activity through independent variation of quadrants 1-4. The second phase involved the preparation of hybrid structures combining the best of these substituents. Further SAR studies and pharmacokinetic considerations led to the identification of N-(2-pyridyl)-N'-(5-bromo-2- pyridyl)-thiourea (62; LY300046 · HCl) as a candidate for clinical evaluation. LY300046 · HCl inhibits HIV-1 RT with an IC50 of 15 nM and in cell culture has an ED50 of 20 nM.