654-01-3 Usage
Uses
Used in Pharmaceutical Industry:
2,6-Difluorophenylacetonitrile is used as a synthetic intermediate for the production of pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Chemical Industry:
2,6-Difluorophenylacetonitrile is used as a chemical intermediate in the synthesis of various organic compounds, including ethyl 4-(2,6-difluorophenyl)-2-ethyl-3-oxobutyrate. 2,6-DIFLUOROPHENYLACETONITRILE has potential applications in the development of new materials and chemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 654-01-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,5 and 4 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 654-01:
(5*6)+(4*5)+(3*4)+(2*0)+(1*1)=63
63 % 10 = 3
So 654-01-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H5F2N/c9-7-2-1-3-8(10)6(7)4-5-11/h1-3H,4H2
654-01-3Relevant academic research and scientific papers
Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency
Bollini, Mariela,Gallardo-Macias, Ricardo,Spasov, Krasimir A.,Tirado-Rives, Julian,Anderson, Karen S.,Jorgensen, William L.
, p. 1110 - 1113 (2013/03/14)
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved activity towards Tyr181Cys containing variants was pursued with the assistance of free energy perturbation (FEP) calculations. Optimization of the 4-R substituent in 1 led to ethyl and isopropyl analogs 1e and 1f with 1-7 nM potency towards both the wild-type virus and a Tyr181C variant.
3-benzyl-1,2,4-triazolo[4,3-α] pyrazines
-
, (2008/06/13)
3-benzyl-1,2,4-triazolo [4,3-α] pyrazines are prepared. They are useful as anticonvulsants.
