172913-96-1

Usage

Uses

Used in Pharmaceutical Research:
(R)-tert-butyl 6-oxopiperidin-3-ylcarbamate is used as a key intermediate in the synthesis of new drugs for [application reason] targeting the central nervous system. Its structural similarities with existing bioactive compounds make it a promising candidate for drug development.
Used in Organic Synthesis:
(R)-tert-butyl 6-oxopiperidin-3-ylcarbamate is used as a building block in the synthesis of various organic compounds for [application reason] the creation of novel pharmaceuticals and other chemical products.
Used in Chemical Research:
(R)-tert-butyl 6-oxopiperidin-3-ylcarbamate is used as a reagent in chemical research for [application reason] exploring its unique properties and potential applications in the development of new chemical processes and compounds.

Upstream product

• 91229-98-0 1-(benzyloxy)-5-<(tert-butyloxycarbonyl)amino>-piperidone 
• 45214-91-3 (2S)-2-[(tert-butoxy)carbonylamino]-4-(methoxycarbonyl)butanoic acid 
• 130223-39-1 methyl 4-<(tert-butyloxycarbonyl)amino>-5-(O-tosyl)pentanoate 
• 330680-83-6 methyl (4S)-5-azido-4-[(tert-butoxycarbonyl)amino]pentanoate 
• 251987-13-0 (4S)-N-benzyloxy-4-(N-tert-butoxycarbonyl)amino-5-[(1-ethoxy)ethoxy]pentanamide 
• 251987-04-9 (5S)-1-tert-butoxycarbonyl-5-(1-ethoxy)ethoxymethyl pyrrolidin-2-one 
• 91229-96-8 (4S)-N-benzyloxy-4-(N-tert-butoxycarbonyl)amino-5-hydroxypentanamide 
• 672883-28-2 4-tert-butoxycarbonylamino-5-methanesulfonyloxy-pentanoic acid methyl ester 
• 126587-35-7 methyl (4S)-4-[(tert-butoxy)carbonylamino]-5-hydroxypentanoate 
• 515863-25-9 (S)-tert-butyl 2-(azidomethyl)-5-oxopyrrolidine-1-carboxylate 
• 93288-20-1 [(2S)-5-oxopyrrolidin-2-yl]methyl methanesulfonate 
• 17342-08-4 (S)-Pyroglutaminol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 672883-95-3 4-(S)-amino-δ-valerolactam hydrochloride 
• 1133960-10-7 (S)-tert-butyl 5-(tert-butoxycarbonylamino)-2-oxopiperidine-1-carboxylate 
• 1133960-11-8 (S)-benzyl 5-(tert-butoxycarbonyl)amino-2-oxopiperidine-1-carboxylate 
• 2365230-46-0 (S)-6,6-dimethylpiperidin-3-amine 
• 1527525-47-8 tert-butyl N-[(3S)-1-[3-methyl-6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-2-pyridyl]-6-oxo-3-piperidyl]carbamate 
• 1527523-89-2 (5S)-5-amino-1-[3-methyl-6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-2-pyridyl]piperidin-2-one 
• 1527525-46-7 tert-butyl N-[(3S)-1-(6-chloro-3-methyl-2-pyridyl)-6-oxo-3-piperidyl]carbamate 
• 154148-70-6 (S)-5-aminopiperidin-2-one 

Relevant academic research and scientific papers

TLR2 MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The present disclosure relates to compounds which modulate the activity of Toll-like receptor (TLR) proteins, including agonists or activators, partial agonists, and antagonists. Of particular interest of compounds that modulate the activity of TLR2, as well as methods of using such compounds to treat cancer and other disorders associated with a TLR2 pathway.

Synthesis of 5-amino- and 4-hydroxy-2-phenylsulfonylmethylpiperidines

Suitable protected 5-amino- and 4-hydroxy-2-phenylsulfonylmethylpiperidines were synthesized from functionalized N-benzyloxycarbonylpiperidin-l-ones through the opening of lactam ring by methyl phenyl sulfone carbanion followed by reductive aminocyclization.

NEW HETEROCYCLIC AMIDE COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention relates to novel heterocyclic compounds that inhibit phosphodiesterase type 4 (PDE 4). The compounds are useful for treating inflammatory conditions, diseases of the central nervous systems and insulin resistant diabetes.

Diastereoselective synthesis of enantiopure differentially protected cis-4,5-diaminopiperidin-2-one through intramolecular transamidation

The diastereoselective synthesis of enantiopure differentially protected cis-4,5-diaminopiperidin-2-one was achieved by means of conjugate addition of ammonia to an unsaturated γ-lactam and transamidation reaction with ring expansion as the main steps.

Synthesis of chiral n,n+1-diamino acids and their application to the construction of dendrimers

Efficient methods for the synthesis of chiral n,n+1-diamino acids starting from L-glutamic acid were developed. A second generation prototype amino acid based dendrimer, containing 1,3-propanediamine as the core and 4,5-diaminopentanoic acid as the branching unit, was synthesised following the divergent approach. Diaminobutane poly(propyleneimine) dendrimers modified at the periphery with n,n+1-diamino acids were synthesized and characterized.

Enantioselective Synthesis of (S)-5-Aminopiperidin-2-one from (S)-Pyroglutaminol

(5S)-5-aminopiperidin-2-one and several derivatives were synthesized from (S)-pyroglutaminol through ring opening and Mitsunobu reaction as the key steps.