172922-91-7Relevant articles and documents
Engineered Th17 Cell Differentiation Using a Photoactivatable Immune Modulator
Chang, Pamela V.,Parasar, Bibudha
supporting information, p. 18103 - 18108 (2020/11/26)
T helper 17 (Th17) cells, an important subset of CD4+ T cells, help to eliminate extracellular infectious pathogens that have invaded our tissues. Despite the critical roles of Th17 cells in immunity, how the immune system regulates the production and maintenance of this cell type remains poorly understood. In particular, the plasticity of these cells or their dynamic ability to trans-differentiate into other CD4+ T cell subsets remains mostly uncharacterized. Here, we report a synthetic immunology approach using a photoactivatable immune modulator (PIM) to increase Th17 cell differentiation on demand with spatial and temporal precision to help elucidate this important and dynamic process. In this chemical strategy, we developed a latent agonist that upon photochemical activation releases a small-molecule ligand that targets the aryl hydrocarbon receptor (AhR) and ultimately induces Th17 cell differentiation. We used this chemical tool to control AhR activation with spatiotemporal precision within cells and to modulate Th17 cell differentiation on demand using UV light illumination. We envision that this approach will enable an understanding of the dynamic functions and behaviors of Th17 cells in vivo during immune responses and in mouse models of inflammatory disease.
Synthesis of metabolites of the Ah receptor ligand 6-formylindolo[3,2-b] carbazole
Wahlstroem, Niklas,Romero, Ivan,Bergman, Jan
, p. 2593 - 2602 (2007/10/03)
Synthesis of the five mono- and di-hydroxylated metabolites of the aryl hydrocarbon receptor high affinity ligand 6-formylindolo[3,2-b]carbazole is described. The structures of the metabolites were unequivocally established as 2-hydroxy-, 8-hydroxy-, 2,10-dihydroxy-, 4,8-dihydroxy- and 2,8- dihydroxyindolo[3,2-b]carbazole-6-carboxaldehyde. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
Synthesis of 6-formylindolo[3,2-b]carbazole, an extremely potent ligand for the aryl hydrogen (Ah) receptor
Tholander, Joakim,Bergman, Jan
, p. 1619 - 1622 (2007/10/03)
Dichloroacetylation of 2,3-diindolylmethane followed by a tandem cyclization-hydrolysis reaction under acidic conditions gave the title compound.