229020-86-4

Basic information

• Product Name: ethyl 5,11-dihydroindolo[3,2-b]carbazole-6-carboxylate
• Synonyms: ethyl 5,11-dihydroindolo[3,2-b]carbazole-6-carboxylate
• CAS NO: 229020-86-4
• Molecular Formula: C21H16N2O2
• Molecular Weight: 328.36394
• EINECS: -0
• Mol File: 229020-86-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: ethyl 5,11-dihydroindolo[3,2-b]carbazole-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5,11-dihydroindolo[3,2-b]carbazole-6-carboxylate(229020-86-4)
• EPA Substance Registry System: ethyl 5,11-dihydroindolo[3,2-b]carbazole-6-carboxylate(229020-86-4)

Safety Data

• Hazardous Substances Data: 229020-86-4(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 4755-77-5 Ethyl oxalyl chloride 
• 114648-66-7 (1H-indol-3-yl)-(1H-indol-2-yl)-methane 
• 229020-85-3 [2-(1H-indol-3-ylmethyl)-1H-indol-3-yl]-oxo-acetic acid ethyl ester 

Downstream Products

• 172922-91-7 6-Formylindolo-(3,2-b)-carbazole 
• 1432053-78-5 (5,11-Dihydroindolo[3,2-b]carbazol-6-yl)methanol 

Relevant articles and documents

Synthesis and biological evaluation of FICZ analogues as agonists of aryl hydrocarbon receptor

The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor involved in multiple biological processes including immune cell differentiation, intestinal function and inflammation. Based on the scaffold of naturally occurring AhR ligand 6

SYNTHESIS OF DIINDOLYLMETHANES AND INDOLO[3,2-B]CARBAZOLES, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Described is a method to make diindolylmethanes and indolyl/pyrrolylmethanes, The method includes the steps of contacting an ether comprising an arylpropargyl moiety and an amine-protected, substituted or unsubstituted aniline moiety with a substituted or

Concise synthesis of 6-formylindolo[3,2-b]carbazole (FICZ)

A concise synthesis of 6-formylindolo[3,2-b]carbazole (FICZ), a potent ligand of the aryl hydrocarbon receptor (AhR), has been established. The conjugate addition of the enolate derived from indolylacetate 2 to 2-chloro-3-formylindole 3 was accomplished. The following cyclization reaction under the acidic conditions gave the indolo[3,2-b]carbazole skeleton.

Platinum-catalyzed tandem indole annulation/arylation for the synthesis of diindolylmethanes and indolo[3,2-b ]carbazoles

Various diindolylmethanes were prepared from propargylic ethers and substituted indoles via a platinum-catalyzed tandem indole annulation/arylation cascade. The resulting diindolylmethanes could be converted to natural product malassezin by formylation or indolo[3,2-b]carbazoles by cyclization.

Synthesis of metabolites of the Ah receptor ligand 6-formylindolo[3,2-b] carbazole

Synthesis of the five mono- and di-hydroxylated metabolites of the aryl hydrocarbon receptor high affinity ligand 6-formylindolo[3,2-b]carbazole is described. The structures of the metabolites were unequivocally established as 2-hydroxy-, 8-hydroxy-, 2,10-dihydroxy-, 4,8-dihydroxy- and 2,8- dihydroxyindolo[3,2-b]carbazole-6-carboxaldehyde. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Syntheses of 6-substituted indolo[3,2-b]carbazoles, including 6- formylindolo[3,2-b]carbazole, an extremely efficient ligand for the TCDD (Ah) receptor

A number of 6-substituted indolo[3,2-b]carbazoles have been synthesized using 2,3-diindolylmethane 5 as a crucial precursor. Most notably, 6- formylindolo[3,2-b]carbazole 3 has been synthesized, and thereby a previously assigned structure has been confirmed. 6-Formylindolo[3,2-b]carbazole 3 is an extremely efficient ligand for the TCDD (Ah) receptor. A much improved synthesis of 2,3-diindolylmethane 5 has also been developed.