172926-95-3Relevant academic research and scientific papers
Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists
Williams, Jodi T.,Gatfield, John,Roch, Catherine,Treiber, Alexander,Jenck, Francois,Bolli, Martin H.,Brotschi, Christine,Sifferlen, Thierry,Heidmann, Bibia,Boss, Christoph
, p. 1054 - 1064 (2015/06/25)
Starting from a thienopiperidine lead compound with high intrinsic clearance in rat and human liver microsomes and low aqueous solubility, a novel series of 1-acyl-2-benzylpyrrolidines were discovered as potent and competitive dual orexin receptor antagon
Discovery and structure-activity relationships of 2-benzylpyrrolidine- substituted aryloxypropanols as calcium-sensing receptor antagonists
Yang, Wu,Wang, Yufeng,Roberge, Jacques Y.,Ma, Zhengping,Liu, Yalei,Lawrence, R. Michael,Rotella, David P.,Seethala, Ramakrishna,Feyen, Jean H. M.,Dickson Jr., John K.
, p. 1225 - 1228 (2007/10/03)
A structure-activity relationship study of the amine portion of the calcilytic compound NPS-2143 resulted in the discovery of substituted 2-benzylpyrrolidines as replacements for the 1,1-dimethyl-2-naphthalen-2-yl- ethylamine. When compared to NPS-2143, a
