97589-55-4Relevant academic research and scientific papers
Discovery and structure-activity relationships of 2-benzylpyrrolidine- substituted aryloxypropanols as calcium-sensing receptor antagonists
Yang, Wu,Wang, Yufeng,Roberge, Jacques Y.,Ma, Zhengping,Liu, Yalei,Lawrence, R. Michael,Rotella, David P.,Seethala, Ramakrishna,Feyen, Jean H. M.,Dickson Jr., John K.
, p. 1225 - 1228 (2007/10/03)
A structure-activity relationship study of the amine portion of the calcilytic compound NPS-2143 resulted in the discovery of substituted 2-benzylpyrrolidines as replacements for the 1,1-dimethyl-2-naphthalen-2-yl- ethylamine. When compared to NPS-2143, a
N-(Trifluoroacetyl)-α-amino Acid Chlorides as Chiral Reagents for Friedel-Crafts Synthesis
Nordlander, J. Eric,Njoroge, F. George,Payne, Mark J.,Warman, Dhiraj
, p. 3481 - 3484 (2007/10/02)
Chiral N-(trifluoroacetyl)-α-amino acid chlorides unergo Friedel-Crafts reaction with benzene and 1,2-dimethoxybenzene under mild conditions commonly with complete (>99percent) preservation of configurational identity.The resultant (trifluoroacetyl)amino ketones may be deoxygenated with Et3SiH or H2/Pd-C in acidic media to the corresponding N-(trifluoroacetyl)-β-arylalkylamines likewise without loss of configurational purity.
