173034-82-7

Basic information

• Product Name: Isoquinoline, 1,2,3,4-tetrahydro-2-[(4-methoxyphenyl)methyl]-
• CAS NO: 173034-82-7
• Molecular Formula: C17H19NO
• Molecular Weight: 253.344
• Mol File: 173034-82-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Isoquinoline, 1,2,3,4-tetrahydro-2-[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 1,2,3,4-tetrahydro-2-[(4-methoxyphenyl)methyl]-(173034-82-7)
• EPA Substance Registry System: Isoquinoline, 1,2,3,4-tetrahydro-2-[(4-methoxyphenyl)methyl]-(173034-82-7)

Safety Data

• Hazardous Substances Data: 173034-82-7(Hazardous Substances Data)

Upstream product

• 1004522-38-6 C₁₇H₂₁NO₂ 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 2746-25-0 p-Methoxybenzyl bromide 
• 824-94-2 p-methoxybenzyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 77671-13-7 1-(4-Methoxybenzyl)-1,2,3,4-tetrahydroisochinolin 
• 88630-43-7 N-propyl-N'-tetrahydroisoquinolinylurea 
• 83491-16-1 N-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide 
• 199480-42-7 1,2,3,4-tetrahydroisoquinolin-2-ylcarbonyl chloride 

Relevant articles and documents

Synthesis of tertiary amines by direct Br?nsted acid catalyzed reductive amination

Tertiary amines are ubiquitous and valuable compounds in synthetic chemistry, with a wide range of applications in organocatalysis, organometallic complexes, biological processes and pharmaceutical chemistry. One of the most frequently used pathways to synthesize tertiary amines is the reductive amination reaction of carbonyl compounds. Despite developments of numerous new reductive amination methods in the past few decades, this reaction generally requires non-atom-economic processes with harsh conditions and toxic transition-metal catalysts. Herein, we report simple yet practical protocols using triflic acid as a catalyst to efficiently promote the direct reductive amination reactions of carbonyl compounds on a broad range of substrates. Applications of this new method to generate valuable heterocyclic frameworks and polyamines are also included.

COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS

The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases such as Alzheimer's disease, tauopathy, cerebral amyloid angiopathy, Lewy body disease, dementia, Huntington's disease and prion-based spongiform encelopathy. The invention further provides compounds, methods and pharmaceutical compositions for inhibiting tau protein, Aβ protein or α-synuclein protein aggregation.

Efficient synthesis of N-alkyl tetrahydroisoquinolines by reductive amination

An expedient access to diverse N-alkyl 1,2,3,4-tetrahydroisoquinolines is reported by reductive amination of aldehydes and ketones with tetrahydroisoquinoline (THIQ) in the presence of Ti(Oi-Pr)4 and NaBH4. The N-alkyl THIQ products