173035-83-1Relevant academic research and scientific papers
Palladium-catalysed asymmetric allylic substitution: Synthesis of α- and β-amino acids
Bower, Justin F.,Jumnah, Roshan,Williams, Andrew C.,Williams, Jonathan M. J.
, p. 1411 - 1420 (2007/10/03)
Methodology has been established for the formation of enantiomerically enriched α-amino acids using palladium-catalysed allylic amination. The formation of enantiomerically enriched allylamines has been achieved with high enantioselectivity. Oxidative cleavage of the allylamines provides arylglycine and glutamic acid derivatives. Additionally, enantiomerically enriched β-amino acids have been prepared in high enantiomeric excess. Palladium-catalysed asymmetric allylic substitution is used as the key synthetic transformation.
Enantioselective Synthesis of Succinic Acids and γ-Lactones via Palladium Catalysed Allylic Substitution Reactions
Dawson, Graham J.,Williams, Jonathan M. J.,Coote, Steven J.
, p. 2535 - 2546 (2007/10/03)
The palladium catalyzed reaction between non-symmetrical allyl acetates and sodiodimethylmalonate proceeds in high yields and enantioselectivities (up to 99percent ee) using a diphenylphosphinoaryl oxazoline ligand.The so-formed substitution products are transformed into enantiomerically enriched succinic acids and also into enantiomerically enriched γ-lactones.
