68844-05-3

Basic information

• Product Name: (S)-3-Phenyl-4-hydroxybutyric acid 1,4-lactone
• Synonyms: (4S)-4-Phenyl-4,5-dihydrofuran-2(3H)-one;(4S)-4β-Phenyltetrahydrofuran-2-one;(S)-3-Phenyl-4-hydroxybutyric acid 1,4-lactone;(S)-4,5-Dihydro-4-phenyl-2(3H)-furanone;(S)-4β-Phenyl-4,5-dihydro-2(3H)-furanone;4β-Phenyl-4,5-dihydrofuran-2(3H)-one
• CAS NO: 68844-05-3
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 0
• Mol File: 68844-05-3.mol
• Article Data: 76

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-3-Phenyl-4-hydroxybutyric acid 1,4-lactone(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Phenyl-4-hydroxybutyric acid 1,4-lactone(68844-05-3)
• EPA Substance Registry System: (S)-3-Phenyl-4-hydroxybutyric acid 1,4-lactone(68844-05-3)

Safety Data

• Hazardous Substances Data: 68844-05-3(Hazardous Substances Data)

Usage

General Description

(S)-3-Phenyl-4-hydroxybutyric acid 1,4-lactone is a chemical compound that is a lactone derivative of (S)-3-phenyl-4-hydroxybutyric acid. It is known for its chiral properties and is used in the pharmaceutical industry for the synthesis of chiral drugs and other biologically active compounds. (S)-3-Phenyl-4-hydroxybutyric acid 1,4-lactone has potential applications in the development of new pharmaceuticals, particularly in the area of cardiovascular and central nervous system disorders. Additionally, it has been studied for its potential antioxidant and anticancer properties, making it an interesting compound for further research and development.

Upstream product

• 52784-31-3 3-Phenylcyclobutanone 
• 1575-47-9 4-phenyl-5H-furan-2-one 
• 85217-69-2 cinnamyl methyl carbonate 
• 121925-53-9 4-ethoxy-4-oxo-2-phenylbutanoic acid 
• 34971-27-2 cis,trans-4-Phenyl-3-carbethoxy-tetrahydrofuran-2-on 
• 135094-06-3 (-)-(S,S)-4-Hydroxy-3-phenyl-N-(1-phenylethyl)butanamide 
• 497-23-4 2-buten-4-olide 
• 98-80-6 phenylboronic acid 
• 2243-35-8 2-acetoxyacetophenone 
• 1008-73-7 4-phenyldihydrofuran-2(3H)-one 
• 93503-12-9 4-acetoxy-3-phenylbutanoic acid ethyl ester 
• 532-27-4 1-chloroacetophenone 
• 6006-81-1 3-hydroxy-2-phenylpropene 
• 13866-28-9 2,2-dichloro-3-phenylcyclobutanone 

Downstream Products

• 5352-72-7 (+)-(R)-5-oxotetrahydro-3-furancarboxylic acid 
• 133056-58-3 (-)-(S,1S,3S)-N-<2-<2-(4,5-Dimethoxy-2-methyl-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>-4-hydroxy-3-phenylbutanamide 
• 133056-58-3 (-)-(S,1R,3S)-N-<2-<2-(4,5-Dimethoxy-2-methyl-1-naphthyl)3,5-dimethoxyphenyl>-1-methylethyl>-4-hydroxy-3-phenylbutanamide 
• 133056-58-3 (+)-(R,1S,3R)-N-<2-<2-(4,5-Dimethoxy-2-methyl-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>-4-hydroxy-3-phenylbutanamide 
• 133056-58-3 (+)-(R,1R,3R)-N-<2-<2-(4,5-Dimethoxy-2-methyl-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>-4-hydroxy-3-phenylbutanamide 

Relevant articles and documents

Chiral Synthesis of 3-Substituted and 3,3-Disubstituted γ-Butyrolactones by Enantioselective Deprotonation Strategy

Chiral synthesis of 3-substituted and 3,3-disubstituted γ-butyrolactones was achieved by employing an enantioselctive deprotonation of the corresponding cyclobutanone derivatives with chiral bases as a key reaction.

The rationale for stereoinduction in conjugate addition to alkylidenemalonates bearing a menthol-derived chiral auxiliary

Density-functional theory (DFT) calculations provided a new model to rationalize the stereoselectivity in the asymmetric addition to alkylidenemalonate bearing 8-phenylmenthyl groups as a chiral auxiliary. The diastereoselectivity in the addition reactions of a tetramethyldioxolanyl radical with various alkyl 8-phenylmenthyl benzylidenemalonates strongly supports the proposed model.

Investigation of a New Type I Baeyer–Villiger Monooxygenase from Amycolatopsis thermoflava Revealed High Thermodynamic but Limited Kinetic Stability

Baeyer–Villiger monooxygenases (BVMOs) are remarkable biocatalysts, but, due to their low stability, their application in industry is hampered. Thus, there is a high demand to expand on the diversity and increase the stability of this class of enzyme. Sta

Phosphothreonine (pThr)-Based Multifunctional Peptide Catalysis for Asymmetric Baeyer-Villiger Oxidations of Cyclobutanones

Biologically inspired phosphothreonine (pThr)-embedded peptides that function as chiral Br?nsted acid catalysts for enantioselective Baeyer-Villiger oxidations (BV) of cyclobutanones with aqueous H2O2 are reported herein. Complementa