13698-23-2

Upstream product

• 70522-70-2 5-methoxy-2-(4-methoxy-phenyl)-7-(tetra-O-methyl-β-D-glucopyranosyloxy)-chromen-4-one 
• 404853-80-1 Hepta-O-methyl-linarin 
• 111922-60-2 7-O-benzyl-5-O-methylacacetin 
• 77-78-1 dimethyl sulfate 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 3602-54-8 4,6-dihydroxy-2-methoxyacetophenone 
• 39548-89-5 1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethan-1-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 84457-62-5 2'-hydroxy-4'-benzyloxy-4,6'-dimethoxychalkone 
• 84457-62-5 (E)-1-(4-Benzyloxy-2-hydroxy-6-methoxy-phenyl)-3-(4-methoxy-phenyl)-propenone 
• 17306-46-6 rhoifolin 

Downstream Products

• 50461-91-1 3-hydroxy-5,6,7,8,4′-pentamethoxyflavone 
• 34170-18-8 3,5,6,7,8,4′-hexamethoxyflavone 
• 50439-46-8 5-hydroxy-3,6,7,8,4′-pentamethoxyflavone 
• 73213-66-8 7-hydroxy-5,6,8,4′-tetramethoxyflavone 
• 481-53-8 tangeritin 

Relevant academic research and scientific papers

Synthesis of Citrus polymethoxyflavonoids and their antiproliferative activities on Hela cells

Abstract: A series of polymethoxyflavonoids (3–16) were synthesized through dehydrogenation, O-methylation, glycoside hydrolysis, bromination, microwave-assisted aromatic nucleophilic substitution, dimethyldioxirane oxidation and regioselective demethylation, starting from abundant and inexpensive natural sources naringin and hesperidin. All the synthetic compounds were test for antiproliferative activities on human cervical carcinoma Hela cell line by the standard CCK-8 assay, the result showed that most of the target compounds exhibited moderate to potent antiproliferative activities on Hela cells comparable with the positive control cis-Platin. Among them, 5-hydroxypolymethoxy flavonoid 13 showed the strongest activity (IC50 0.791 μM). Graphical Abstract: [InlineMediaObject not available: see fulltext.].

Synthesis of a New Flavone

The structure of the naturally occuring flavone 5-O-methylacacetin (I) has been confirmed by its synthesis. 5,7-Di-O-methylacacetin has been synthesised.